The schizophrenia syndrome, circa 2024: What we know and how that informs its nature
R Tandon, H Nasrallah, S Akbarian… - Schizophrenia …, 2024 - Elsevier
With new data about different aspects of schizophrenia being continually generated, it
becomes necessary to periodically revisit exactly what we know. Along with a need to review …
becomes necessary to periodically revisit exactly what we know. Along with a need to review …
Cross disorder comparisons of brain structure in schizophrenia, bipolar disorder, major depressive disorder, and 22q11. 2 deletion syndrome: a review of ENIGMA …
This review compares the main brain abnormalities in schizophrenia (SZ), bipolar disorder
(BD), major depressive disorder (MDD), and 22q11. 2 Deletion Syndrome (22q11DS) …
(BD), major depressive disorder (MDD), and 22q11. 2 Deletion Syndrome (22q11DS) …
New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications
Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …
The genetic architecture of human cortical folding
D Van Der Meer, T Kaufmann, AA Shadrin… - Science …, 2021 - science.org
The folding of the human cerebral cortex is a highly genetically regulated process that
allows for a much larger surface area to fit into the cranial vault and optimizes functional …
allows for a much larger surface area to fit into the cranial vault and optimizes functional …
Shared genetic architecture between schizophrenia and subcortical brain volumes implicates early neurodevelopmental processes and brain development in …
Patients with schizophrenia have consistently shown brain volumetric abnormalities,
implicating both etiological and pathological processes. However, the genetic relationship …
implicating both etiological and pathological processes. However, the genetic relationship …
Identification of novel genomic risk loci shared between common epilepsies and psychiatric disorders
Psychiatric disorders and common epilepsies are heritable disorders with a high comorbidity
and overlapping symptoms. However, the causative mechanisms underlying this …
and overlapping symptoms. However, the causative mechanisms underlying this …
Characterizing the shared genetic underpinnings of schizophrenia and cardiovascular disease risk factors
L Rødevand, Z Rahman, GFL Hindley… - American Journal of …, 2023 - Am Psychiatric Assoc
Objective: Schizophrenia is associated with increased risk of cardiovascular disease (CVD),
although there is variation in risk among individuals. There are indications of shared genetic …
although there is variation in risk among individuals. There are indications of shared genetic …
The relationship between cannabis use, schizophrenia, and bipolar disorder: a genetically informed study
Background The relationship between psychotic disorders and cannabis use is heavily
debated. Shared underlying genetic risk is one potential explanation. We investigated the …
debated. Shared underlying genetic risk is one potential explanation. We investigated the …
Transcriptional level of inflammation markers associates with short-term brain structural changes in first-episode schizophrenia
Background Inflammation has been implicated in the pathology of schizophrenia and may
cause neuronal cell death and dendrite loss. Neuroimaging studies have highlighted …
cause neuronal cell death and dendrite loss. Neuroimaging studies have highlighted …
Mapping the genetic architecture of cortical morphology through neuroimaging: progress and perspectives
D van der Meer, T Kaufmann - Translational Psychiatry, 2022 - nature.com
Cortical morphology is a key determinant of cognitive ability and mental health. Its
development is a highly intricate process spanning decades, involving the coordinated …
development is a highly intricate process spanning decades, involving the coordinated …