Multi-omics integration in biomedical research–A metabolomics-centric review
Recent advances in high-throughput technologies have enabled the profiling of multiple
layers of a biological system, including DNA sequence data (genomics), RNA expression …
layers of a biological system, including DNA sequence data (genomics), RNA expression …
Metabolomics for clinical use and research in chronic kidney disease
B Hocher, J Adamski - Nature Reviews Nephrology, 2017 - nature.com
Chronic kidney disease (CKD) has a high prevalence in the general population and is
associated with high mortality; a need therefore exists for better biomarkers for diagnosis …
associated with high mortality; a need therefore exists for better biomarkers for diagnosis …
Microbiome as a therapeutic target in alcohol-related liver disease
Alcohol-related liver disease is associated with significant changes in gut microbial
composition. The transmissibility of ethanol-induced liver disease has been demonstrated …
composition. The transmissibility of ethanol-induced liver disease has been demonstrated …
[HTML][HTML] Metabolomics in nutritional epidemiology: identifying metabolites associated with diet and quantifying their potential to uncover diet-disease relations in …
Background: Metabolomics is an emerging field with the potential to advance nutritional
epidemiology; however, it has not yet been applied to large cohort studies. Objectives: Our …
epidemiology; however, it has not yet been applied to large cohort studies. Objectives: Our …
Lipidomics reveals associations of phospholipids with obesity and insulin resistance in young adults
Context: Obesity and related diseases have become a global public health burden.
Identifying biomarkers will lead to a better understanding of the underlying mechanisms …
Identifying biomarkers will lead to a better understanding of the underlying mechanisms …
Effects of metformin on metabolite profiles and LDL cholesterol in patients with type 2 diabetes
T Xu, S Brandmaier, AC Messias, C Herder… - Diabetes …, 2015 - Am Diabetes Assoc
OBJECTIVE Metformin is used as a first-line oral treatment for type 2 diabetes (T2D).
However, the underlying mechanism is not fully understood. Here, we aimed to …
However, the underlying mechanism is not fully understood. Here, we aimed to …
[HTML][HTML] Identification of candidate metabolite biomarkers for metabolic syndrome and its five components in population-based human cohorts
M Shi, S Han, K Klier, G Fobo, C Montrone, S Yu… - Cardiovascular …, 2023 - Springer
Abstract Background Metabolic Syndrome (MetS) is characterized by risk factors such as
abdominal obesity, hypertriglyceridemia, low high-density lipoprotein cholesterol (HDL-C) …
abdominal obesity, hypertriglyceridemia, low high-density lipoprotein cholesterol (HDL-C) …
Intestinal dysbiosis and permeability: the yin and yang in alcohol dependence and alcoholic liver disease
Alcohol dependence and alcoholic liver disease represent a major public health problem
with substantial morbidity and mortality. By yet incompletely understood mechanisms …
with substantial morbidity and mortality. By yet incompletely understood mechanisms …
Metabolic profiling of alcohol consumption in 9778 young adults
P Würtz, S Cook, Q Wang, M Tiainen… - International journal …, 2016 - academic.oup.com
Background: High alcohol consumption is a major cause of morbidity, yet alcohol is
associated with both favourable and adverse effects on cardiometabolic risk markers. We …
associated with both favourable and adverse effects on cardiometabolic risk markers. We …
[HTML][HTML] Beyond genomics: understanding exposotypes through metabolomics
Background Over the past 20 years, advances in genomic technology have enabled
unparalleled access to the information contained within the human genome. However, the …
unparalleled access to the information contained within the human genome. However, the …