DEAD-box ATPases constitute a very large protein family present in all cells, often in great
abundance. From bacteria to humans, they play critical roles in many aspects of RNA …

Proteins with motifs rich in arginines and glycines were discovered decades ago and are
functionally involved in a staggering range of essential processes in the cell. Versatile …

The human DEAD-box protein DDX3X is an RNA remodelling enzyme that has been
implicated in various aspects of RNA metabolism. In addition, like many DEAD-box proteins …

Guanine-rich DNA sequences may fold back into non-canonical four-stranded secondary
structures termed as G-quadruplexes. The role of G-quadruplexes has already been well …

Abstract mRNA translation is tightly regulated by various classes of RNA-binding proteins
(RBPs) during development and in response to changing environmental conditions. In this …

Protein− nucleic acid interactions, including the interac-tions of proteins with DNA, RNA, and
DNA/RNA hybrid, often confer important biological consequences to targeted nucleic acids …

Human DDX5 and its yeast ortholog Dbp2 are ATP-dependent RNA helicases that play a
key role in normal cell processes, cancer development, and viral infection. The crystal …

Abstract G-quadruplexes (G4s) are important in regulating DNA replication, repair and RNA
transcription through interactions with specialized proteins. Dbp2 has been identified as a …

Continuously renewing the proteome, translation is exquisitely controlled by a number of
dedicated factors that interact with the ribosome. The RNA helicase DDX3 belonging to the …

In guanine-rich DNA strands, base-base interactions among guanines allow the
conformational shift from the B-form DNA to the non-canonical quadruplex or G4 structure …