Sickle cell anemia (SCA or SS homozygous sickle cell disease) is an inherited blood
disorder caused by single nucleotide substitution in the ß-globin gene that renders their …

Rationale: Pulmonary complications of sickle cell anemia (Hb-SS) commonly cause
morbidity, yet few large studies of pulmonary function tests (PFTs) in this population have …

Many studies report estimated pulmonary artery systolic pressure (ePASP) in patients with
sickle cell disease (SCD) screened by echocardiography. To better understand the …

Given the progress in the symptomatic treatment of breathlessness, and the physical and
psychological morbidity associated with chronic breathlessness, estimates of the size of the …

BACKGROUND: The Medical Research Council (MRC) chronic dyspnea scale (6-point) is
used in different clinical conditions to grade breathlessness on daily activities. We have …

Objectives To prospectively assess longitudinal lung function in children with sickle cell
disease (SCD). Working hypothesis Lung function in SCD children deteriorates with …

Prior studies of asthma in children with sickle cell disease (SCD) were based on reports of a
doctor‐diagnosis of asthma with limited description of asthma features. Doctor‐diagnoses of …

Sickle cell disease (SCD) is a genetic hemoglobinopathy leading to 2 major clinical
manifestations: severe chronic hemolytic anemia and iterative vaso-occlusive crises. SCD is …

Rationale: Patient factors associated with development of abnormal lung function in children
with sickle cell anemia (SCA) have not been fully characterized. Objectives: To characterize …

Summary Objectives and Working Hypothesis Airways obstruction occurs in young children
with sickle cell disease (SCD). Our aim was to test the hypothesis that increased pulmonary …