C-JUN overexpressing CAR-T cells in acute myeloid leukemia: preclinical characterization and phase I trial
S Zuo, C Li, X Sun, B Deng, Y Zhang, Y Han… - Nature …, 2024 - nature.com
Chimeric antigen receptor (CAR) T cells show suboptimal efficacy in acute myeloid leukemia
(AML). We find that CAR T cells exposed to myeloid leukemia show impaired activation and …
(AML). We find that CAR T cells exposed to myeloid leukemia show impaired activation and …
Monocyte biology conserved across species: Functional insights from cattle
SC Talker, GT Barut, HEL Lischer, R Rufener… - Frontiers in …, 2022 - frontiersin.org
Similar to human monocytes, bovine monocytes can be split into CD14highCD16-classical,
CD14highCD16high intermediate and CD14-/dimCD16high nonclassical monocytes (cM …
CD14highCD16high intermediate and CD14-/dimCD16high nonclassical monocytes (cM …
ANP32A regulates histone H3 acetylation and promotes leukemogenesis
Deregulation of key regulators of histone modification is important in the initiation and
progression of human leukemia. Acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) …
progression of human leukemia. Acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) …
A three-platelet mRNA set: MAX, MTURN and HLA-B as biomarker for lung cancer
L Liu, X Song, X Li, L Xue, S Ding, L Niu, L Xie… - Journal of cancer …, 2019 - Springer
Background During the development of tumors, tumors “educate” platelets causing changes
in their mRNAs expression profiles and phenotypes, thereby, tumor-educated platelet (TEP) …
in their mRNAs expression profiles and phenotypes, thereby, tumor-educated platelet (TEP) …
TEP RNA: a new frontier for early diagnosis of NSCLC
Y Wang, A Dong, M Jin, S Li, Y Duan - Journal of Cancer Research and …, 2024 - Springer
Background Non-small cell lung cancer (NSCLC) is the most common type of lung cancer
(LC), which is the leading cause of tumor mortality. In recent years, compared with tissue …
(LC), which is the leading cause of tumor mortality. In recent years, compared with tissue …
Induction of INKIT by viral infection negatively regulates antiviral responses through inhibiting phosphorylation of p65 and IRF3
The transcription factors p65 and IRF3 play key roles in the induction of cellular antiviral
responses. Phosphorylation of p65 and IRF3 is required for their activity and constitutes a …
responses. Phosphorylation of p65 and IRF3 is required for their activity and constitutes a …
Novel function of FAXDC2 in megakaryopoiesis
Q Jin, Y Ren, M Wang, PK Suraneni, D Li… - Blood cancer …, 2016 - nature.com
FAXDC2 (fatty acid hydroxylase domain containing 2) is a member of the fatty acid
hydroxylase superfamily. Given the important role of fatty acids in megakaryocytes, we have …
hydroxylase superfamily. Given the important role of fatty acids in megakaryocytes, we have …
C-Jun/C7ORF41/NF-κB axis mediates hepatic inflammation and lipid accumulation in NAFLD
FJ Yan, X Wang, SE Wang, HT Hong, J Lu… - Biochemical …, 2020 - portlandpress.com
Nonalcoholic fatty liver disease (NAFLD) is an expanding health problem worldwide.
Although many studies have made great efforts to elucidate the pathogenesis of NAFLD, the …
Although many studies have made great efforts to elucidate the pathogenesis of NAFLD, the …
SIPA1L3 methylation modifies the benefit of smoking cessation on lung adenocarcinoma survival: an epigenomic–smoking interaction analysis
Smoking cessation prolongs survival and decreases mortality of patients with non‐small‐cell
lung cancer (NSCLC). In addition, epigenetic alterations of some genes are associated with …
lung cancer (NSCLC). In addition, epigenetic alterations of some genes are associated with …
Benzene metabolite hydroquinone promotes DNA homologous recombination repair via the NF-κB pathway
Benzene, a widespread environmental pollutant, induces DNA double-strand breaks (DSBs)
and DNA repair, which may further lead to oncogenic mutations, chromosomal …
and DNA repair, which may further lead to oncogenic mutations, chromosomal …