Rheumatoid Arthritis — Common Origins, Divergent Mechanisms | New England Journal of
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Type 2 immunity mediates protective responses to helminths and pathological responses to
allergens, but it also has broad roles in the maintenance of tissue integrity, including wound …

In vitro studies have associated oxidative phosphorylation (OXPHOS) with anti-inflammatory
macrophages, whereas pro-inflammatory macrophages rely on glycolysis. However, the …

The Krebs cycle-derived metabolite itaconate and its derivatives suppress the inflammatory
response in pro-inflammatory" M1" macrophages. However, alternatively activated" M2" …

Nonresolving inflammation contributes to many diseases, including COVID-19 in its fatal and
long forms. Our understanding of inflammation is rapidly evolving. Like the immune system …

Inflammation must be tightly regulated to both defend against pathogens and restore tissue
homeostasis. The resolution of inflammatory responses is a dynamic process orchestrated …

Tissue‐resident cardiac macrophage subsets mediate cardiac tissue inflammation and
repair after acute myocardial infarction (AMI). CC chemokine receptor 2 (CCR2)‐expressing …

Acetyl-CoA carboxylase (ACC) regulates lipid synthesis; however, its role in inflammatory
regulation in macrophages remains unclear. We generated mice that are deficient in both …

Macrophages as innate immune cells with great plasticity are of great interest for cell
therapy. There are two main macrophage populations–pro-and anti-inflammatory cells also …

Interleukin-33 (IL-33), a member of the IL-1 cytokine family and a multifunctional cytokine,
plays critical roles in maintaining host homeostasis and in pathological conditions, such as …