KS Zaret - Annual review of genetics, 2020 - annualreviews.org
Pioneer transcription factors have the intrinsic biochemical ability to scan partial DNA sequence motifs that are exposed on the surface of a nucleosome and thus access silent …
AC Schier, DJ Taatjes - Genes & development, 2020 - genesdev.cshlp.org
Abstract RNA polymerase II (Pol II) transcribes all protein-coding genes and many noncoding RNAs in eukaryotic genomes. Although Pol II is a complex, 12-subunit enzyme, it …
The primary regulators of metazoan gene expression are enhancers, originally functionally defined as DNA sequences that can activate transcription at promoters in an orientation …
J Rodriguez, DR Larson - Annual review of biochemistry, 2020 - annualreviews.org
Transcription in several organisms from certain bacteria to humans has been observed to be stochastic in nature: toggling between active and inactive states. Periods of active nascent …
K Wagh, M Ishikawa, DA Garcia, DA Stavreva… - Trends in cell …, 2021 - cell.com
Mechanotransduction is the ability of a cell to sense mechanical cues from its microenvironment and convert them into biochemical signals to elicit adaptive transcriptional …
E Tunnacliffe, JR Chubb - Trends in Genetics, 2020 - cell.com
The idea that gene activity can be discontinuous will not surprise many biologists–many genes are restricted in when and where they can be expressed. Yet during the past 15 …
K Wagh, DA Stavreva, A Upadhyaya… - Annual Review of Cell …, 2023 - annualreviews.org
Cells must tightly regulate their gene expression programs and yet rapidly respond to acute biochemical and biophysical cues within their environment. This information is transmitted to …
Transcription factors (TFs) regulate gene expression by binding to specific consensus motifs within the local chromatin context. The mechanisms by which TFs navigate the nuclear …
M Palacio, DJ Taatjes - Journal of Molecular Biology, 2022 - Elsevier
The regulation of RNA polymerase II (pol II) transcription requires a complex and context- specific array of proteins and protein complexes, as well as nucleic acids and metabolites …