Cohesin is a chromosome-associated multisubunit protein complex that is highly conserved
in eukaryotes and has close homologs in bacteria. Cohesin mediates cohesion between …

Structural maintenance of chromosomes (SMC) proteins are chromosomal ATPases, highly
conserved from bacteria to humans, that play fundamental roles in many aspects of higher …

The centrosome organizes the microtubule cytoskeleton and consists of a pair of centrioles
surrounded by pericentriolar material. Cells begin the cell cycle with a single centrosome …

In order to facilitate the identification of factors and pathways in the cellular response to UV-
induced DNA damage, several descriptive proteomic screens and a functional genomics …

The existence and functioning of intrinsically disordered proteins (IDPs) challenge the
classical structure-function paradigm that equates function with a well-defined 3D structure …

Pituitary tumor-transforming gene-1 (PTTG1) is overexpressed in a variety of endocrine-
related tumors, especially pituitary, thyroid, breast, ovarian, and uterine tumors, as well as …

ATM/ATR‐like protein kinases play central roles in the maintenance of genome stability and
phosphorylate numerous substrates in response to DNA damage, preferentially on SQ or TQ …

Nutrients are essential for cell growth and division. Screening of Schizosaccharomyces
pombe temperature‐sensitive strains led to the isolation of a nutrient‐insensitive mutant, tor2 …

The cohesin complex, named for its key role in sister chromatid cohesion, also plays critical
roles in gene regulation and DNA repair. It performs all three functions in single cell …

The structural maintenance of chromosomes (Smc) proteins regulate nearly all aspects of
chromosome biology and are critical for genomic stability. In eukaryotes, six Smc proteins …