Forster resonance energy transfer (FRET) is a nonradiative transfer of energy between two
fluorescent molecules (a donor and an acceptor) in nanometer range proximity. FRET …

There has been recently a considerable interest in simultaneously reconstructing yield and
lifetime distributions of fluorescent imaging agents inside a bulky tissue, since combined …

Förster, or fluorescence, resonance energy transfer (FRET) provides fluorescence signals
sensitive to intra-and inter-molecular distances in the 1 to 10 nm range. Widely applied in …

This work demonstrates the usefulness of 3D printing for optical imaging applications.
Progress in developing optical imaging for biomedical applications requires customizable …

Fluorescence lifetime imaging (FLIM) aims at quantifying the exponential decay rate of
fluorophores to yield lifetime maps over the imaged sample. When combined with Förster …

Many cancer cells over-express folate receptors, and this provides an opportunity for both
folate-targeted fluorescence imaging and the development of targeted anti-cancer drugs. We …

A super-resolution optical imaging method is presented that relies on the distinct temporal
information associated with each fluorescent optical reporter to determine its spatial position …

We demonstrate the in vivo reconstruction of all fluorescence resonance energy transfer
(FRET) parameters, including the nanometer donor–acceptor distance, in a mouse. The …

We report a three-dimensional time-resolved tomographic imaging technique for localizing
protein-protein interaction and protein conformational changes in turbid media based on …

Despite the broad impact in medicine that optics can bring, thus far practical approaches are
limited to weak scatter or near-surface monitoring. We show a method that utilizes a laser …