Statins: Adverse reactions, oxidative stress and metabolic interactions

A Liu, Q Wu, J Guo, I Ares, JL Rodríguez… - Pharmacology & …, 2019 - Elsevier
Abstract Statins, 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, are currently
the most effective lipid-lowering drugs, effectively reducing the plasma total cholesterol and …

Overview of the Anticancer Potential of the “King of Spices” Piper nigrum and Its Main Constituent Piperine

E Turrini, P Sestili, C Fimognari - Toxins, 2020 - mdpi.com
The main limits of current anticancer therapy are relapses, chemoresistance, and toxic
effects resulting from its poor selectivity towards cancer cells that severely impair a patient's …

Piperine ameliorates ischemic stroke-induced brain injury in rats by regulating the PI3K/AKT/mTOR pathway

Y Zhang, M Yang, Q Yuan, Q He, H Ping, J Yang… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Piperine (PIP), a main active component isolated from
Piper nigrum L., exerts neuroprotective effects in a rat model of ischemic stroke (IS) …

Herb–drug interaction studies of herbs used in treatment of cardiovascular disorders—A narrative review of preclinical and clinical studies

AS Shaikh, AB Thomas, SS Chitlange - Phytotherapy research, 2020 - Wiley Online Library
About 70% of the world population is currently using medicinal herbs as complementary or
alternative medicine, which is increasing at a tremendous pace in both developed and …

Piperine-mediated drug interactions and formulation strategy for piperine: Recent advances and future perspectives

SH Lee, HY Kim, SY Back, HK Han - Expert opinion on drug …, 2018 - Taylor & Francis
Introduction: Piperine has various pharmacological effects and can modulate the functional
activity of metabolic enzymes and drug transporters. Consequently, there is a great interest …

Piperine: Chemical, biological and nanotechnological applications

CR Quijia, VH Araujo, M Chorilli - Acta pharmaceutica, 2021 - hrcak.srce.hr
Sažetak Piperine (PIP) is an alkaloid present in several species of piper, mainly Piper
nigrum Linn. and P. longum, among other species. The present article provides a …

Safety aspects of the use of isolated piperine ingested as a bolus

R Ziegenhagen, K Heimberg, A Lampen… - Foods, 2021 - mdpi.com
Piperine is a natural ingredient of Piper nigrum (black pepper) and some other Piper
species. Compared to the use of pepper for food seasoning, piperine is used in food …

Development and evaluation of a novel drug delivery: Soluplus®/TPGS mixed micelles loaded with piperine in vitro and in vivo

Y Ding, C Wang, Y Wang, Y Xu, J Zhao… - Drug development …, 2018 - Taylor & Francis
Background: Although piperine can inhibit cells of tumors, the poor water solubility restricted
its clinical application. This paper aimed to develop mixed micelles based on Soluplus® and …

Лекарственные растения и медикаменты

ИД Кароматов, МР Рахматова, ВЗ Жалолова - 2020 - elibrary.ru
В монографии собраны результаты научных исследований по взаимодействию пищи и
лекарств и лекарственных средств растительного происхождения и современных …

Quality by design–based development and optimization of fourth-generation ternary solid dispersion of standardized Piper longum extract for melanoma therapy

D Mohapatra, DN Kumar, S Shreya, V Pandey… - Drug Delivery and …, 2023 - Springer
The study aimed to enhance the solubility, dissolution, and oral bioavailability of
standardized Piper longum fruits ethanolic extract (PLFEE) via fourth-generation ternary …