Cell biology and pathophysiology of α-synuclein

J Burré, M Sharma, TC Südhof - Cold Spring …, 2018 - perspectivesinmedicine.cshlp.org
α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve
terminals. Genetics and neuropathology studies link α-synuclein to Parkinson's disease (PD) …

The emerging role of α-synuclein truncation in aggregation and disease

ZA Sorrentino, BI Giasson - Journal of Biological Chemistry, 2020 - ASBMB
α-Synuclein (αsyn) is an abundant brain neuronal protein that can misfold and polymerize to
form toxic fibrils coalescing into pathologic inclusions in neurodegenerative diseases …

Human α-synuclein-harboring familial Parkinson's disease-linked Ala-53→ Thr mutation causes neurodegenerative disease with α-synuclein aggregation in …

MK Lee, W Stirling, Y Xu, X Xu, D Qui… - Proceedings of the …, 2002 - National Acad Sciences
Mutations in α-synuclein (α-Syn) cause Parkinson's disease (PD) in a small number of
pedigrees with familial PD. Moreover, α-Syn accumulates as a major component of Lewy …

Impact of the acidic C-terminal region comprising amino acids 109− 140 on α-synuclein aggregation in vitro

W Hoyer, D Cherny, V Subramaniam, TM Jovin - Biochemistry, 2004 - ACS Publications
The aggregation of α-synuclein, involved in the pathogenesis of several neurodegenerative
disorders such as Parkinson's disease, is enhanced in vitro by biogenic polyamines binding …

Role of α-synuclein carboxy-terminus on fibril formation in vitro

IVJ Murray, BI Giasson, SM Quinn, V Koppaka… - Biochemistry, 2003 - ACS Publications
Alpha-synuclein (α-syn) is the major component of intracellular inclusions in several
neurodegenerative diseases, and the conversion of soluble α-syn into filamentous …

Part II: α-synuclein and its molecular pathophysiological role in neurodegenerative disease

KK Dev, K Hofele, S Barbieri, VL Buchman… - …, 2003 - Elsevier
α-Synuclein (αSN) brain pathology is a conspicuous feature of several neurodegenerative
diseases. These include prevalent conditions such as Parkinson's disease (PD), dementia …

Physiological C-terminal truncation of α-synuclein potentiates the prion-like formation of pathological inclusions

ZA Sorrentino, N Vijayaraghavan, KM Gorion… - Journal of Biological …, 2018 - ASBMB
α-Synuclein (αsyn) aggregates into toxic fibrils in multiple neurodegenerative diseases
where these fibrils form characteristic pathological inclusions such as Lewy bodies (LBs) …

Proteotoxicity and neurodegenerative diseases

C Ruz, JL Alcantud, F Vives Montero, R Duran… - International journal of …, 2020 - mdpi.com
Neurodegenerative diseases are a major burden for our society, affecting millions of people
worldwide. A main goal of past and current research is to enhance our understanding of the …

Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's disease

H Vicente Miranda, R Cássio, L Correia-Guedes… - Scientific reports, 2017 - nature.com
Parkinson's disease (PD) is a progressive neurodegenerative disorder known for the typical
motor features associated. Pathologically, it is characterized by the intracellular …

Structural insights on physiological functions and pathological effects of±‐synuclein

M Bisaglia, S Mammi, L Bubacco - The FASEB Journal, 2009 - Wiley Online Library
α‐Synuclein is an intrinsically unfolded protein that can adopt a partially helical structure
when it interacts with different lipid membranes. Its pathological relevance is linked to its …