NK cells for cancer immunotherapy

N Shimasaki, A Jain, D Campana - Nature reviews Drug discovery, 2020 - nature.com
Natural killer (NK) cells can swiftly kill multiple adjacent cells if these show surface markers
associated with oncogenic transformation. This property, which is unique among immune …

[HTML][HTML] Innate lymphoid cells: 10 years on

E Vivier, D Artis, M Colonna, A Diefenbach, JP Di Santo… - Cell, 2018 - cell.com
Innate lymphoid cells (ILCs) are lymphocytes that do not express the type of diversified
antigen receptors expressed on T cells and B cells. ILCs are largely tissue-resident cells and …

Natural killer cells: development, maturation, and clinical utilization

AM Abel, C Yang, MS Thakar… - Frontiers in …, 2018 - frontiersin.org
Natural killer (NK) cells are the predominant innate lymphocyte subsets that mediate anti-
tumor and anti-viral responses, and therefore possess promising clinical utilization. NK cells …

The role of natural killer cells in autoimmune diseases

UC Kucuksezer, E Aktas Cetin, F Esen… - Frontiers in …, 2021 - frontiersin.org
Natural killer (NK) cells, the large granular lymphocytes differentiated from the common
lymphoid progenitors, were discovered in early 1970's. They are members of innate …

Exploiting innate immunity for cancer immunotherapy

M Yi, T Li, M Niu, Q Mei, B Zhao, Q Chu, Z Dai, K Wu - Molecular cancer, 2023 - Springer
Immunotherapies have revolutionized the treatment paradigms of various types of cancers.
However, most of these immunomodulatory strategies focus on harnessing adaptive …

The broad spectrum of human natural killer cell diversity

AG Freud, BL Mundy-Bosse, J Yu, MA Caligiuri - Immunity, 2017 - cell.com
Natural killer (NK) cells provide protection against infectious pathogens and cancer. For
decades it has been appreciated that two major NK cell subsets (CD56 bright and CD56 …

Plasticity of innate lymphoid cell subsets

SM Bal, K Golebski, H Spits - Nature Reviews Immunology, 2020 - nature.com
Innate lymphoid cells (ILCs) are important for tissue homeostasis and for the initiation of
immune responses. Based on their transcriptional regulation and cytokine profiles, ILCs can …

Systemic human ILC precursors provide a substrate for tissue ILC differentiation

AI Lim, Y Li, S Lopez-Lastra, R Stadhouders, F Paul… - Cell, 2017 - cell.com
Innate lymphoid cells (ILCs) represent innate versions of T helper and cytotoxic T cells that
differentiate from committed ILC precursors (ILCPs). How ILCPs give rise to mature tissue …

Heterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome

C Yang, JR Siebert, R Burns, ZJ Gerbec… - Nature …, 2019 - nature.com
Natural killer (NK) cells are critical to both innate and adaptive immunity. However, the
development and heterogeneity of human NK cells are yet to be fully defined. Using single …

NK cells and type 1 innate lymphoid cells: partners in host defense

H Spits, JH Bernink, L Lanier - Nature immunology, 2016 - nature.com
Innate lymphoid cells (ILCs) are effectors and regulators of innate immunity and tissue
modeling and repair. Researchers have identified subsets of ILCs with differing functional …