Historically, the term 'keratin'stood for all of the proteins extracted from skin modifications,
such as horns, claws and hooves. Subsequently, it was realized that this keratin is actually a …

Mechanically induced signal transduction has an essential role in development. Cells
actively transduce and respond to mechanical signals and their internal architecture must …

Epithelia are exposed to multiple forms of stress. Keratin intermediate filaments are
abundant in epithelia and form cytoskeletal networks that contribute to cell type–specific …

Desmosomes are prominent adhesion sites that are tightly associated with the cytoplasmic
intermediate filament cytoskeleton providing mechanical stability in epithelia and also in …

Cell migration and invasion are largely dependent on the complex organization of the
various cytoskeletal components. Whereas the role of actin filaments and microtubules in …

In pemphigus vulgaris, a life-threatening autoimmune skin disease, epidermal blisters are
caused by autoantibodies primarily targeting desmosomal cadherins desmoglein 3 (DSG3) …

The effects of shear stress on the keratin intermediate filament (KIF) cytoskeleton of cultured
human alveolar epithelial (A549) cells have been investigated. Under normal culture …

Over recent years the role of biomarkers in anticancer drug development has expanded
across a spectrum of applications ranging from research tool during early discovery to …

Keratin filaments form cytoskeletal networks in epithelial cells. Dynamic rearrangement of
keratin filament networks is required for epithelial cells to perform cellular processes such as …

It is generally assumed that turnover of the keratin filament system occurs by exchange of
subunits along its entire length throughout the cytoplasm. We now present evidence that a …