The arrangement (syntax) of transcription factor (TF) binding motifs is an important part of the
cis-regulatory code, yet remains elusive. We introduce a deep learning model, BPNet, that …

The compaction of linear DNA into micrometer-sized nuclear boundaries involves the
establishment of specific three-dimensional (3D) DNA structures complexed with histone …

In the heart of innate and adaptive immunity lies the proper spatiotemporal development of
several immune cell lineages. Multiple studies have highlighted the necessity of epigenetic …

Abstract N 6-methyladenine (N 6-mA) of DNA is an emerging epigenetic mark in mammalian
genome. Levels of N 6-mA undergo drastic fluctuation during early embryogenesis …

Mechanisms of tissue-specific gene expression regulation via 3D genome organization are
poorly understood. Here we uncover the regulatory chromatin network of developing T cells …

The recent discovery of N 6-methyladenine (N 6-mA) in mammalian genomes suggests that
it may serve as an epigenetic regulatory mechanism. However, the biological role of N 6-mA …

Whereas large-scale statistical analyses can robustly identify disease-gene relationships,
they do not accurately capture genotype-phenotype correlations or disease mechanisms …

Special AT-rich sequence binding protein 1 (SATB1) has long been proposed to act as a
global chromatin loop organizer in T cells. However, the exact functions of SATB1 in spatial …

Abstract Yes-associated protein 1 (YAP) is a transcriptional regulator with critical roles in
mechanotransduction, organ size control, and regeneration. Here, using advanced tools for …

Aims Syncope is a common and clinically challenging condition. In this study, the genetics of
syncope were investigated to seek knowledge about its pathophysiology and prognostic …