Many anecdotal observations exist of a regulatory effect of DNA methylation on gene
expression. However, in general, the underlying mechanisms of this effect are poorly …

In higher organisms, all cells share the same genome, but every cell expresses only a
limited and specific set of genes that defines the cell type. During cell division, not only the …

MeCP2 is an essential transcriptional repressor that mediates gene silencing through
binding to methylated DNA. Binding specificity has been thought to depend on hydrophobic …

Abstract cis-diamminedichloroplatinum (II)(cisplatin) is a powerful anti-tumor drug whose
target is cellular DNA. In the reaction between DNA and cisplatin, covalent intrastrand and …

DNA methylation plays an essential role in transcriptional control of organismal
development in epigenetics, from turning off a specific gene to inactivation of entire …

Epigenetics as a modifiable risk factor in periodontal diseases has been investigated in light
of the current knowledge of how chronic infection and inflammation can affect gene‐specific …

The fundamental question of how sequence defines conformation is explicitly answered if
the structures of all possible sequences of a macromolecule are determined. We present …

DNA methylation is a prevalent epigenetic modification involved in regulating a number of
essential cellular processes, including genomic accessibility and transcriptional outcomes …

Transcription factor binding and high resolution crystallographic studies (1.3 Å) of Dickerson–
Drew duplexes with cytosine, methylcytosine and hydroxymethylcytosine bases provide …

Cancer cells and tissues exhibit genome wide hypomethylation and regional
hypermethylation. CpG-methylation of DNA (Me CpG-DNA) is defined as the formation of a …