The canonical Wnt–β-catenin pathway is a complex, evolutionarily conserved signalling
mechanism that regulates fundamental physiological and pathological processes. Wnt–β …

Primary liver cancer is the second leading cause of cancer-related death worldwide and
therefore a major public health challenge. We review hypotheses of the cell of origin of liver …

Liver cancer has the second highest worldwide cancer mortality rate and has limited
therapeutic options. We analyzed 363 hepatocellular carcinoma (HCC) cases by whole …

Hepatitis B virus (HBV) contributes to hepatocellular carcinoma (HCC) development through
direct and indirect mechanisms. HBV DNA integration into the host genome occurs at early …

Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death. Its
mortality has increased in Western populations, with a minority of patients diagnosed at …

Hepatocellular carcinoma (HCC), the fastest rising cancer in the United States and
increasing in Europe, often occurs with nonalcoholic steatohepatitis (NASH). Mechanisms …

MYC regulates a complex biological program by transcriptionally activating and repressing
its numerous target genes. As such, MYC is a master regulator of many processes, including …

Hepatoblastoma (HB) is the most common pediatric liver malignancy; however, hereditary
predisposition and acquired molecular aberrations related to HB clinicopathological …

β-catenin (encoded by CTNNB1) is a subunit of the cell surface cadherin protein complex
that acts as an intracellular signal transducer in the WNT signaling pathway; alterations in its …

Tumor microenvironment (TME) takes critical roles in tumor resistance to immune checkpoint
inhibitors (ICIs) including anti-programmed death-1 (PD-1) or anti-programmed death-ligand …