In the present article, the steps involved in the process of tumor metastasis are discussed.
Several events are required for malignant cells to leave the primary tumor and proliferate at …

Tissue inhibitors of metalloproteinases (TIMPs) are endogenous inhibitors of matrix
metalloproteinases (MMPs) and the balance between MMPs/TIMPs regulates the …

The hereditary macular dystrophies are progressive degenerations of the central retina and
contribute significantly to irreversible visual loss in developed countries. Among these …

Matrix metalloproteinases (MMPs) are enzymes with important roles in a variety of normal
physiological processes; these same enzymes are also operative in a range of pathologies …

Several families of enzymes are responsible for the degradation of extracellular matrix
(ECM) proteins during the remodeling of tissues. An important family of such enzymes is that …

Background—The accumulation of macrophage-derived foam cells in atherosclerotic
lesions correlates with increased local release of matrix-degrading metalloproteinases …

The tissue inhibitors of metalloproteinases (TIMPs) are natural inhibitors of the matrix
metalloproteinases, a group of zinc-binding endopeptidases involved in the degradation of …

The TIMPs play an important role in regulating the activity of the secreted metalloproteinases
(collagenases, stromelysins, gelatinases). Two different TIMPs have been well …

Background—To define the role of metalloproteinases (MMPs) in the development of lipid-
rich atherosclerotic lesions in relation to the balance between proteolytic and antiproteolytic …

A central role in tissue invasion is played by proteases that degrade extracellular matrices;
in particular specific metalloproteases (MMPs) have been frequently correlated with the …