Bacterial or virus co-infections with severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) have been reported in many studies, however, the knowledge on Aspergillus co …

The prevalence of obesity in adults and children is rapidly increasing across the world.
Several general (patho) physiological alterations associated with obesity have been …

Early prediction of clearance mechanisms allows for the rapid progression of drug discovery
and development programs, and facilitates risk assessment of the pharmacokinetic …

Silymarin, which is extracted from the milk thistle (Silybum marianum), has been used for
centuries for treating hepatic disorders and its hepatoprotective effects have been known for …

Background Management of drug–drug interactions (DDIs) for ensitrelvir, a novel 3-
chymotrypsin-like protease inhibitor of SARS-CoV-2 infection is crucial. A previous clinical …

OATP1B1 and OATP1B3 are transporters that are expressed on the sinusoidal membrane of
hepatocytes; they accept a number of therapeutic reagents as their substrates. In vitro and in …

Efavirenz is a highly effective HIV-1 antiretroviral; however, it is also frequently associated
with neuropsychiatric adverse events (NPAE) that include abnormal dreams, sleep …

Induction of cytochrome P450 3A4 (CYP3A4) expression is often implicated in clinically
relevant drug-drug interactions (DDI), as metabolism catalyzed by this enzyme is the …

The aim of the present paper was to present an overview of the current status of the methods
used to predict the magnitude of pharmacokinetic drug–drug interactions (DDIs) which are …

Sažetak Over the past few decades, physiologically-based pharmacokinetic modelling
(PBPK) has been anticipated to be a powerful tool to improve the productivity of drug …