Longevity and healthy aging are among the most complex phenotypes studied to date. The
heritability of age at death in adulthood is approximately 25%. Studies of exceptionally long …

With each trajectory taken during the ontogeny of an individual, the number of optional
behavioural phenotypes that can be expressed across its life span is reduced. The initial …

Aging is characterized by progressive loss of physiological and cellular functions, but the
molecular basis of this decline remains unclear. We explored how aging affects …

Sarcopenia is the age‐related decline in muscle mass and function without any underlying
disease. The exact molecular mechanisms responsible for this pathology remain unknown …

Even though more than 30 years have passed since the eradication of smallpox, high titers
of smallpox-specific antibodies are still detected in the blood of subjects vaccinated in …

Exposure to chronic stress is a leading pre-disposing factor for several neuropsychiatric
disorders as it often leads to maladaptive responses. The response to stressful events is …

Mammals differ more than 100‐fold in maximum lifespan, which can be altered in either
direction during evolution, but the molecular basis for natural changes in longevity is not …

Genetic factors clearly contribute to exceptional longevity and healthy aging in humans, yet
the identification of the underlying genes remains a challenge. Longevity is a complex …

Despite the dramatic increase in human lifespan over the past century, there remains
pronounced variability in “health‐span,” or the period of time in which one is generally …

Human ageing is a fundamental biological process that leads to functional decay, increased
risk for various diseases and, ultimately, death. Some of the basic biological mechanisms …