Sickle cell anemia (SCA) is a genetic disease caused by the homozygosity of the HBB: c.
20A> T mutation, which results in the production of hemoglobin S (HbS). In hypoxic …

The primary β-globin gene mutation that causes sickle cell disease (SCD) has significant
pathophysiological consequences that result in hemolytic events and the induction of the …

The interests in blood endothelial cells arise from their therapeutic potential in vascular
repair and regeneration. Our understanding of blood endothelial cells that exist in the …

The coronavirus disease 2019 (COVID-19) pandemic, a viral illness caused by the severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2), 1 has produced at the time of this …

Development of therapeutic approaches to treat vascular dysfunction and thrombosis at
disease-and patient-specific levels is an exciting proposed direction in biomedical research …

This study aimed to comprehensively analyze inflammatory and autoimmune characteristics
of patients with sickle cell disease (SCD) at a steady-state condition (StSt) compared to …

Introduction: The mutation of the beta-globin gene that causes sickle cell disease (SCD)
results in pleiotropic effects, such as hemolysis and vaso-occlusive crisis that can induce …

Endothelial colony-forming cells (ECFCs) are endothelial progenitor cells circulating in a
limited number in peripheral blood. They can give rise to mature endothelial cells (ECs) and …

Sickle cell disease (SCD) is the most prevalent inherited blood disorder in the world. But the
clinical manifestations of the disease are highly variable. In particular, it is currently difficult …

Idiopathic systemic capillary leak syndrome (SCLS) is a rare and potentially fatal vascular
disorder characterized by reversible bouts of hypotension and edema resulting from fluid …