Covering: up to the end of 2006The catalytic potential of the P450s in organic
biotransformations is the subject of this review—with emphasis on the breadth of P450 redox …

The human pathogen Mycobacterium tuberculosis has made a dramatic resurgence in
recent years. Drug resistant and multidrug resistant strains are prevalent, and novel …

The obligatory step in sterol biosynthesis in eukaryotes is demethylation of sterol precursors
at the C14-position, which is catalyzed by CYP51 (sterol 14-alpha demethylase) in three …

During lung infection, Mycobacterium tuberculosis resides in macrophages and subverts the
bactericidal mechanisms of these professional phagocytes. Comprehension of this host …

Sterol 14α-demethylase (14DM, the CYP51 family of cytochrome P450) is an essential
enzyme in sterol biosynthesis in eukaryotes. It serves as a major drug target for fungal …

Sterol biosynthesis, primarily associated with eukaryotic kingdoms of life, occurs as an
abbreviated pathway in the bacterium Methylococcus capsulatus. Sterol 14α-demethylation …

A series of analogues of cyclo (l-tyrosyl-l-tyrosine), the substrate of the Mycobacterium
tuberculosis enzyme CYP121, have been synthesized and analyzed by UV–vis and electron …

NidA3B3 is a terminal dioxygenase whose favorable substrates are high-molecular-weight
polyaromatic hydrocarbons (PAHs) from Mycobacterium vanbaalenii PYR-1, a powerful …

The cytochrome P450 superfamily of heme-thiolate monooxygenase enzymes can catalyse
various oxidation reactions. The addition of a substrate or an inhibitor ligand induces …

CYP 51 is an enzyme of sterol biosynthesis pathway present in animals, plants, protozoa
and fungi. This enzyme is described as an important drug target that is still of interest …