Kraepelin, in his early descriptions of schizophrenia (SZ), characterized the illness as having
“an orchestra without a conductor.” Kraepelin further speculated that this “conductor” was …

Lines of evidence coming from many branches of neuroscience indicate that anxiety
disorders arise from a dysfunction in the modulation of brain circuits which regulate …

Abstract gamma-Aminobutyric acid (GABA)-mediated inhibitory neurotransmission and the
gene products involved were discovered during the mid-twentieth century. Historically …

Certain clinical features of schizophrenia, such as working memory disturbances, appear to
emerge from altered gamma oscillatory activity in the prefrontal cortex (PFC). Given the …

Major depressive disorder (MDD) is a leading cause of distress, disability, and suicides. As
per the latest WHO report, MDD affects more than 260 million people worldwide. Despite …

The inhibitory gamma‐aminobutyric acid (GABA) system is involved in the etiology of most
psychiatric disorders, including schizophrenia, autism spectrum disorder (ASD) and major …

Over the past two decades, research has identified extrasynaptic GABA A receptor
populations that enable neurons to sense the low ambient GABA concentrations present in …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized clinically by severe
cognitive deficits and pathologically by amyloid plaques, neuronal loss, and neurofibrillary …

Ionic currents and the network-driven patterns they generate differ in immature and adult
neurons: The developing brain is not a “small adult brain.” One of the most investigated …

Positive allosteric modulators of γ-aminobutyric acid-A (GABA A) receptors or GABAkines
have been widely used medicines for over 70 years for anxiety, epilepsy, sleep, and other …