GLUT, SGLT, and SWEET: Structural and mechanistic investigations of the glucose transporters
Glucose is the primary fuel to life on earth. Cellular uptake of glucose is a fundamental
process for metabolism, growth, and homeostasis. Three families of secondary glucose …
process for metabolism, growth, and homeostasis. Three families of secondary glucose …
A glimpse of membrane transport through structures—advances in the structural biology of the GLUT glucose transporters
N Yan - Journal of molecular biology, 2017 - Elsevier
The cellular uptake of glucose is an essential physiological process, and movement of
glucose across biological membranes requires specialized transporters. The major facilitator …
glucose across biological membranes requires specialized transporters. The major facilitator …
Crystal structure of the human glucose transporter GLUT1
The glucose transporter GLUT1 catalyses facilitative diffusion of glucose into erythrocytes
and is responsible for glucose supply to the brain and other organs. Dysfunctional mutations …
and is responsible for glucose supply to the brain and other organs. Dysfunctional mutations …
Molecular basis of ligand recognition and transport by glucose transporters
The major facilitator superfamily glucose transporters, exemplified by human GLUT1–4,
have been central to the study of solute transport. Using lipidic cubic phase crystallization …
have been central to the study of solute transport. Using lipidic cubic phase crystallization …
Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides
K Kapoor, JS Finer-Moore… - Proceedings of the …, 2016 - National Acad Sciences
Cancerous cells have an acutely increased demand for energy, leading to increased levels
of human glucose transporter 1 (hGLUT1). This up-regulation suggests hGLUT1 as a target …
of human glucose transporter 1 (hGLUT1). This up-regulation suggests hGLUT1 as a target …
PI3K/mTOR inhibitors promote G6PD autophagic degradation and exacerbate oxidative stress damage to radiosensitize small cell lung cancer
H Deng, Y Chen, L Wang, Y Zhang, Q Hang, P Li… - Cell Death & …, 2023 - nature.com
Our previous study revealed that PI3K/AKT/mTOR signaling was associated with SCLC
radioresistance. SBC2 cells were used as primary radioresistance models, while H446 cells …
radioresistance. SBC2 cells were used as primary radioresistance models, while H446 cells …
Molecular basis for inhibiting human glucose transporters by exofacial inhibitors
Human glucose transporters (GLUTs) are responsible for cellular uptake of hexoses.
Elevated expression of GLUTs, particularly GLUT1 and GLUT3, is required to fuel the …
Elevated expression of GLUTs, particularly GLUT1 and GLUT3, is required to fuel the …
An appraisal of the current status of inhibition of glucose transporters as an emerging antineoplastic approach: Promising potential of new pan-GLUT inhibitors
Neoplastic cells displayed altered metabolism with accelerated glycolysis. Therefore, these
cells need a mammoth supply of glucose for which they display an upregulated expression …
cells need a mammoth supply of glucose for which they display an upregulated expression …
[HTML][HTML] Curcumin inhibits lung cancer invasion and metastasis by attenuating GLUT1/MT1-MMP/MMP2 pathway
H Liao, Z Wang, Z Deng, H Ren, X Li - International journal of …, 2015 - ncbi.nlm.nih.gov
Glucose transporter (GLUT) 1 is found highly expressed in malignant tumors and considered
a mediator inducing cancer metastasis. Curcumin is a natural product which exerts anti …
a mediator inducing cancer metastasis. Curcumin is a natural product which exerts anti …
GLUT-1 overexpression as an unfavorable prognostic biomarker in patients with colorectal cancer
J Yang, J Wen, T Tian, Z Lu, Y Wang, Z Wang… - …, 2016 - pmc.ncbi.nlm.nih.gov
Background Glucose transporter-1 (GLUT-1) exhibits altered expression in colorectal cancer
(CRC). The aim of this study was to explore the association between GLUT-1 and survival …
(CRC). The aim of this study was to explore the association between GLUT-1 and survival …