Mammalian Pumilio proteins, PUM1 and PUM2, are members of the PUF family of sequence-
specific RNA-binding proteins. In this review, we explore their mechanisms, regulatory …

Posttranscriptional gene expression including splicing, RNA transport, translation, and RNA
decay provides an important regulatory layer in many if not all molecular pathways …

Schizophrenia (SZ) is a complex disease characterized by impaired neuronal functioning.
Although defective alternative splicing has been linked to SZ, the molecular mechanisms …

Dysfunction of mRNA or RNA-binding proteins (RBPs) causes cellular aging and age-
related degenerative diseases; however, information regarding the mechanism through …

Fragile X syndrome (FXS), a heritable intellectual and autism spectrum disorder (ASD),
results from the loss of Fragile X mental retardation protein (FMRP). This …

Despite extensive studies on mammalian neurogenesis, its post-transcriptional regulation
remains under-explored. Here we report that neural-specific inactivation of two murine post …

Although numerous long noncoding RNAs (lncRNAs) have been identified, our
understanding of their roles in mammalian physiology remains limited. Here, we …

Human Pumilio proteins, PUM1 and PUM2, are sequence specific RNA-binding proteins
that regulate protein expression. We used RNA-seq, rigorous statistical testing and an …

Identifying preventive targets for Alzheimer's disease is a central challenge of modern
medicine. Non-steroidal anti-inflammatory drugs, which inhibit the cyclooxygenase enzymes …

RNA–binding proteins have emerged as causal agents of complex neurological diseases.
Mice deficient for neuronal RNA–binding protein CELF4 have a complex neurological …