Hijacked in cancer: the KMT2 (MLL) family of methyltransferases
Abstract Histone–lysine N-methyltransferase 2 (KMT2) family proteins methylate lysine 4 on
the histone H3 tail at important regulatory regions in the genome and thereby impart crucial …
the histone H3 tail at important regulatory regions in the genome and thereby impart crucial …
Roles and mechanisms of BAP1 deubiquitinase in tumor suppression
The BAP1 gene has emerged as a major tumor suppressor mutated with various
frequencies in numerous human malignancies, including uveal melanoma, malignant …
frequencies in numerous human malignancies, including uveal melanoma, malignant …
BAP1 loss defines a new class of renal cell carcinoma
S Peña-Llopis, S Vega-Rubín-de-Celis, A Liao… - Nature …, 2012 - nature.com
The molecular pathogenesis of renal cell carcinoma (RCC) is poorly understood. Whole-
genome and exome sequencing followed by innovative tumorgraft analyses (to accurately …
genome and exome sequencing followed by innovative tumorgraft analyses (to accurately …
BAP1 and cancer
M Carbone, H Yang, HI Pass, T Krausz… - Nature Reviews …, 2013 - nature.com
BAP1 is a deubiquitylase that is found associated with multiprotein complexes that regulate
key cellular pathways, including the cell cycle, cellular differentiation, cell death …
key cellular pathways, including the cell cycle, cellular differentiation, cell death …
Frequent Mutation of BAP1 in Metastasizing Uveal Melanomas
Metastasis is a defining feature of malignant tumors and is the most common cause of
cancer-related death, yet the genetics of metastasis are poorly understood. We used exome …
cancer-related death, yet the genetics of metastasis are poorly understood. We used exome …
The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21. 1 losses in malignant pleural mesothelioma
Malignant pleural mesotheliomas (MPMs) often show CDKN2A and NF2 inactivation, but
other highly recurrent mutations have not been described. To identify additional driver …
other highly recurrent mutations have not been described. To identify additional driver …
Emerging roles of E2Fs in cancer: an exit from cell cycle control
Mutations of the retinoblastoma tumour suppressor gene (RB1) or components regulating
the RB pathway have been identified in almost every human malignancy. The E2F …
the RB pathway have been identified in almost every human malignancy. The E2F …
Trithorax group proteins: switching genes on and keeping them active
B Schuettengruber, AM Martinez, N Iovino… - … reviews Molecular cell …, 2011 - nature.com
Cellular memory is provided by two counteracting groups of chromatin proteins termed
Trithorax group (TrxG) and Polycomb group (PcG) proteins. TrxG proteins activate …
Trithorax group (TrxG) and Polycomb group (PcG) proteins. TrxG proteins activate …
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia
The CEBPA gene is mutated in 9% of patients with acute myeloid leukemia (AML). Selective
expression of a short (30-kDa) CCAAT-enhancer binding protein-α (C/EBPα) translational …
expression of a short (30-kDa) CCAAT-enhancer binding protein-α (C/EBPα) translational …
Non-canonical MLL1 activity regulates centromeric phase separation and genome stability
Epigenetic dysregulation is a prominent feature in cancer, as exemplified by frequent
mutations in chromatin regulators, including the MLL/KMT2 family of histone …
mutations in chromatin regulators, including the MLL/KMT2 family of histone …