Glutathione-depleting nanomedicines for synergistic cancer therapy

X Cheng, HD Xu, HH Ran, G Liang, FG Wu - ACS nano, 2021 - ACS Publications
Cancer cells frequently exhibit resistance to various molecular and nanoscale drugs, which
inevitably affects the drugs' therapeutic outcomes. Overexpression of glutathione (GSH) has …

Smart nanomaterials in cancer theranostics: challenges and opportunities

BK Kashyap, VV Singh, MK Solanki, A Kumar… - ACS …, 2023 - ACS Publications
Cancer is ranked as the second leading cause of death globally. Traditional cancer
therapies including chemotherapy are flawed, with off-target and on-target toxicities on the …

A metabolic multistage glutathione depletion used for tumor-specific chemodynamic therapy

Y Huang, S Wu, L Zhang, Q Deng, J Ren, X Qu - ACS nano, 2022 - ACS Publications
The high glutathione (GSH) content in tumor cells strongly affects the efficiency of
chemodynamic therapy (CDT). Despite devoted efforts, it still remains a formidable …

Cancer nanomedicine: progress, challenges and opportunities

J Shi, PW Kantoff, R Wooster, OC Farokhzad - Nature reviews cancer, 2017 - nature.com
The intrinsic limits of conventional cancer therapies prompted the development and
application of various nanotechnologies for more effective and safer cancer treatment …

Advances in redox-responsive drug delivery systems of tumor microenvironment

X Guo, Y Cheng, X Zhao, Y Luo, J Chen… - Journal of …, 2018 - Springer
With the improvement of nanotechnology and nanomaterials, redox-responsive delivery
systems have been studied extensively in some critical areas, especially in the field of …

Macrotheranostic probe with disease‐activated near‐infrared fluorescence, photoacoustic, and photothermal signals for imaging‐guided therapy

X Zhen, J Zhang, J Huang, C Xie, Q Miao… - Angewandte …, 2018 - Wiley Online Library
Theranostics provides opportunities for precision cancer therapy. However, theranostic
probes that simultaneously turn on their diagnostic signal and pharmacological action only …

Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient cancers to mTOR inhibition

N Kong, W Tao, X Ling, J Wang, Y Xiao, S Shi… - Science Translational …, 2019 - science.org
Loss of function in tumor suppressor genes is commonly associated with the
onset/progression of cancer and treatment resistance. The p53 tumor suppressor gene, a …

Self-assembled minimalist multifunctional theranostic nanoplatform for magnetic resonance imaging-guided tumor photodynamic therapy

H Zhang, K Liu, S Li, X Xin, S Yuan, G Ma, X Yan - ACS nano, 2018 - ACS Publications
Minimalist multifunctional platforms for delivering diagnostic and therapeutic agents
effectively and safely into tumor sites are highly desired in nanomedicine. Herein, we …

Multi‐stimuli nanocomposite therapeutic: docetaxel targeted delivery and synergies in treatment of human breast cancer tumor

R Taheri‐Ledari, W Zhang, M Radmanesh… - Small, 2020 - Wiley Online Library
A versatile breast cancer‐targeting nanocomposite therapeutic combining docetaxel (DXL),
polyvinyl alcohol (PVA) network for controlled release, and silica‐protected magnetic iron …

Poly (disulfide) s: from synthesis to drug delivery

R Zhang, T Nie, Y Fang, H Huang, J Wu - Biomacromolecules, 2021 - ACS Publications
Bioresponsive polymers have been widely used in drug delivery because of their
degradability. For example, poly (disulfide) s with repeating disulfide bonds in the main …