Advances in histone demethylase KDM4 as cancer therapeutic targets

DH Lee, GW Kim, YH Jeon, J Yoo, SW Lee… - The FASEB …, 2020 - Wiley Online Library
Abstract The KDM4 subfamily H3K9 histone demethylases are epigenetic regulators that
control chromatin structure and gene expression by demethylating histone H3K9, H3K36 …

Histone lysine demethylase (KDM) subfamily 4: structures, functions and therapeutic potential

RM Labbé, A Holowatyj… - American journal of …, 2013 - pmc.ncbi.nlm.nih.gov
KDM4 histone demethylases catalyze the removal of methyl marks from histone lysine
residues to epigenetically regulate chromatin structure and gene expression. KDM4 …

JmjC-KDMs KDM3A and KDM6B modulate radioresistance under hypoxic conditions in esophageal squamous cell carcinoma

C Macedo-Silva, V Miranda-Gonçalves… - Cell Death & …, 2020 - nature.com
Esophageal squamous cell carcinoma (ESCC), the most frequent esophageal cancer (EC)
subtype, entails dismal prognosis. Hypoxia, a common feature of advanced ESCC, is …

Phenolic acids-mediated regulation of molecular targets in Ovarian Cancer: current understanding and future perspectives

N Nazam, NR Jabir, I Ahmad, SA Alharthy, MS Khan… - Pharmaceuticals, 2023 - mdpi.com
Cancer is a global health concern with a dynamic rise in occurrence and one of the leading
causes of mortality worldwide. Among different types of cancer, ovarian cancer (OC) is the …

Potential therapeutic implications of caffeic acid in cancer signaling: past, present, and future

M Alam, GM Ashraf, K Sheikh, A Khan, S Ali… - Frontiers in …, 2022 - frontiersin.org
Caffeic acid (CA) has been present in many herbs, vegetables, and fruits. CA is a bioactive
compound and exhibits various health advantages that are linked with its anti-oxidant …

The JMJD family histone demethylases in crosstalk between inflammation and cancer

J Yang, Y Hu, B Zhang, X Liang, X Li - Frontiers in immunology, 2022 - frontiersin.org
Inflammation has emerged as a key player in regulating cancer initiation, progression, and
therapeutics, acting as a double edged sword either facilitating cancer progression and …

Overexpression of Stathmin 1 correlates with poor prognosis and promotes cell migration and proliferation in oesophageal squamous cell carcinoma

PZ Ni, JZ He, ZY Wu, X Ji, LQ Chen… - Oncology …, 2017 - spandidos-publications.com
Abstract Stathmin 1 (STMN1) is a microtubule-regulated protein that plays an important role
in tumour cell proliferation and migration. Overexpression of STMN1 is associated with …

The critical role of hypoxic microenvironment and epigenetic deregulation in esophageal cancer radioresistance

C Macedo-Silva, V Miranda-Gonçalves, R Henrique… - Genes, 2019 - mdpi.com
Esophageal cancer (EC) is the seventh most common cancer worldwide and the sixth
leading cause of death, according to Globocan 2018. Despite efforts made for therapeutic …

Overexpression of suprabasin is associated with proliferation and tumorigenicity of esophageal squamous cell carcinoma

J Zhu, G Wu, Q Li, H Gong, J Song, L Cao, S Wu… - Scientific reports, 2016 - nature.com
Suprabasin is a recently identified oncoprotein that is upregulated in multiple cancers.
However, the clinical significance and biological role of suprabasin in human esophageal …

A three‐gene signature and clinical outcome in esophageal squamous cell carcinoma

LL Sun, JY Wu, ZY Wu, JH Shen, XE Xu… - … journal of cancer, 2015 - Wiley Online Library
It is increasingly apparent that cancer development depends not only on genetic alterations,
but also on epigenetic changes involving histone modifications. GASC1, member of the …