This Minireview highlights recent developments in radical trifluoromethylation reactions. The
trifluoromethyl group belongs to the privileged moieties in medicinal chemistry. Many drugs …

Very few fields in chemistry have shown such a considerable interest as fluoroorganic
chemistry. Fluorine is perhaps the element that has experienced the greatest recent interest …

The first enantioselective, organocatalytic α-trifluoromethylation and α-perfluoroalkylation of
aldehydes have been accomplished using a readily available iridium photocatalyst and a …

Recent advances in the development of new strategies in nucleophilic, electrophilic, and
radical trifluoromethylations are reviewed. The emphasis is given to the description of the …

The incorporation of a CF3 group in a compound of pharmacological relevance usually
results in significant enhancement of its lipophilicity, binding selectivity, and metabolic …

No transition metal! Fluorinated hypervalent‐iodine reagents react with TEMPONa in the
presence of an alkene under mild conditions to give the corresponding …

Fluorinated motifs are frequently encountered in drugs and agrochemicals. Incorporating
fluorine-containing motifs in drug candidates for lead optimization in pharmaceutical …

The combo pack: Copper‐catalyzed trifluoromethylation of alkenes bearing an allylic proton
combined with C C bond formation affords the title compounds in good to high yields (see …

Enantioselective Cu-catalyzed trifluoromethylation of β-ketoesters using commercially
available trifluoromethylating reagents is reported. A number of α-CF3 β-ketoesters are …

A family of practical, liquid trifluoromethylation and pentafluoroethylation reagents is
described. We show how halogen bonding can be used to obtain easily handled liquid …