MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
R Rupaimoole, FJ Slack - Nature reviews Drug discovery, 2017 - nature.com
In just over two decades since the discovery of the first microRNA (miRNA), the field of
miRNA biology has expanded considerably. Insights into the roles of miRNAs in …
miRNA biology has expanded considerably. Insights into the roles of miRNAs in …
Clustered miRNAs and their role in biological functions and diseases
MicroRNAs (miRNAs) are endogenous, small non‐coding RNAs known to regulate
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …
LncRNA PTAR promotes EMT and invasion-metastasis in serous ovarian cancer by competitively binding miR-101-3p to regulate ZEB1 expression
H Liang, T Yu, Y Han, H Jiang, C Wang, T You, X Zhao… - Molecular cancer, 2018 - Springer
Abstract Background Ovarian cancer (OvCa) is one of the most common malignant diseases
of the female reproductive system in the world. The majority of OvCa is diagnosed with …
of the female reproductive system in the world. The majority of OvCa is diagnosed with …
The role of epithelial-to-mesenchymal plasticity in ovarian cancer progression and therapy resistance
Ovarian cancer is the most lethal of all gynecologic malignancies and the eighth leading
cause of cancer-related deaths among women worldwide. The main reasons for this poor …
cause of cancer-related deaths among women worldwide. The main reasons for this poor …
[HTML][HTML] Properties and behavior of carbon nanomaterials when interfacing neuronal cells: How far have we come?
In the last two decades, an increasing amount of studies have investigated the use of
components based on carbon-(nano) materials in the engineering of neural interfaces, to …
components based on carbon-(nano) materials in the engineering of neural interfaces, to …
Epithelial–mesenchymal transition: The history, regulatory mechanism, and cancer therapeutic opportunities
Epithelial–mesenchymal transition (EMT) is a program wherein epithelial cells lose their
junctions and polarity while acquiring mesenchymal properties and invasive ability …
junctions and polarity while acquiring mesenchymal properties and invasive ability …
Tumor immune microenvironment and its related miRNAs in tumor progression
Y Xing, G Ruan, H Ni, H Qin, S Chen, X Gu… - Frontiers in …, 2021 - frontiersin.org
MiRNA is a type of small non-coding RNA, by regulating downstream gene expression that
affects the progression of multiple diseases, especially cancer. MiRNA can participate in the …
affects the progression of multiple diseases, especially cancer. MiRNA can participate in the …
ZEB1: a critical regulator of cell plasticity, DNA damage response, and therapy resistance
The predominant way in which conventional chemotherapy kills rapidly proliferating cancer
cells is the induction of DNA damage. However, chemoresistance remains the main obstacle …
cells is the induction of DNA damage. However, chemoresistance remains the main obstacle …
Role of Rad51 and DNA repair in cancer: A molecular perspective
The maintenance of genome integrity is essential for any organism survival and for the
inheritance of traits to offspring. To the purpose, cells have developed a complex DNA repair …
inheritance of traits to offspring. To the purpose, cells have developed a complex DNA repair …
Platinum and PARP inhibitor resistance due to overexpression of microRNA-622 in BRCA1-mutant ovarian cancer
High-grade serous ovarian carcinomas (HGSOCs) with BRCA1/2 mutations exhibit
improved outcome and sensitivity to double-strand DNA break (DSB)-inducing agents (ie …
improved outcome and sensitivity to double-strand DNA break (DSB)-inducing agents (ie …