Brain endocannabinoid (eCB) signalling influences the motivation for natural rewards (such
as palatable food, sexual activity and social interaction) and modulates the rewarding effects …

The endocannabinoid system is up-regulated in numerous pathophysiological states such
as inflammatory, neurodegenerative, gastrointestinal, metabolic and cardiovascular …

Anandamide is a lipid mediator that acts as an endogenous ligand of CB1 receptors. These
receptors are also the primary molecular target responsible for the pharmacological effects …

Transient increases in nucleus accumbens (NAc) dopamine concentration are observed
when animals are presented with motivationally salient stimuli and are theorized to energize …

Since the discovery of endocannabinoids and their receptors, two major members of the
endocannabinoid family, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), have been …

Substance use disorder (SUD) is a major public health crisis worldwide, and effective
treatment options are limited. During the past 2 decades, researchers have investigated the …

The endocannabinoid system consists of cannabinoid CB1 and CB2 receptors, of
endogenous agonists for these receptors known as 'endocannabinoids', and of processes …

Over the last decades, the endocannabinoid system has been implicated in a large variety of
functions, including a crucial modulation of brain-reward circuits and the regulation of …

Electronic (E)-cigarettes are the latest form of nicotine delivery device and are highly popular
in the general population. It is currently unknown whether vaping E-cigarettes (E-CIGs) …

The last decade has provided a wealth of experimental data on the role played by lipids
belonging to the endocannabinoid family in several facets of physiopathology of dopamine …