Epithelial-mesenchymal transition (EMT) is described as the process in which injured renal
tubular epithelial cells undergo a phenotype change, acquiring mesenchymal characteristics …

Renal fibrosis, especially tubulointerstitial fibrosis, is the inevitable outcome of all
progressive chronic kidney diseases (CKDs) and exerts a great health burden worldwide …

Senescent cells have undergone permanent growth arrest, adopt an altered secretory
phenotype, and accumulate in the kidney and other organs with ageing and injury …

Diabetic nephropathy (DN), a severe microvascular complication frequently associated with
both type 1 and type 2 diabetes mellitus, is a leading cause of renal failure. The condition …

Acute kidney injury (AKI) is a major public health concern associated with high morbidity and
mortality. Despite decades of research, the pathogenesis of AKI remains incompletely …

Kidney fibrosis is the unavoidable consequence of chronic kidney disease irrespective of the
primary underlying insult. It is a complex phenomenon governed by the interplay between …

Acute kidney injury (AKI) is an important clinical issue that is associated with significant
morbidity and mortality. Despite research advances over the past decades, the complex …

Acute kidney injury (AKI), caused by various stimuli including ischemia reperfusion,
nephrotoxic insult, and sepsis, is characterized by abrupt decline of kidney function. Till now …

The renal tubules are the major component of the kidney and are vulnerable to a variety of
injuries including ischemia, proteinuria, toxins, and metabolic disorders. It has long been …

Abstract p53 is a major regulator of cell cycle arrest, apoptosis, and senescence. While
involvement of p53 in tumorigenesis is well established, recent studies implicate p53 in the …