Molecular switches—the ON and OFF of bacterial phase variation

IR Henderson, P Owen, JP Nataro - Molecular microbiology, 1999 - Wiley Online Library
The expression of most bacterial genes is controlled at the level of transcription via promoter
control mechanisms that permit a graded response. However, an increasing number of …

Common themes in microbial pathogenicity

BB Finlay, S Falkow - Microbiological reviews, 1989 - Am Soc Microbiol
A bacterial pathogen is a highly adapted microorganism which has the capacity to cause
disease. The mechanisms used by pathogenic bacteria to cause infection and disease …

Fibronectin binding mediated by a novel class of surface organelles on Escherichia coll

A Olsén, A Jonsson, S Normark - Nature, 1989 - nature.com
GRAM-negative bacteria are known to produce two types of surface organelles: flagella,
which are required for motility and chemotaxis, and pili (fimbriae), which play a part in the …

A dissemination-prone morphotype enhances extrapulmonary organ entry by Cryptococcus neoformans

ST Denham, B Brammer, KY Chung, MA Wambaugh… - Cell host & …, 2022 - cell.com
Environmental pathogens move from ecological niches to mammalian hosts, requiring
adaptation to dramatically different environments. Microbes that disseminate farther …

Identification of invasin: a protein that allows enteric bacteria to penetrate cultured mammalian cells

RR Isberg, DL Voorhis, S Falkow - Cell, 1987 - cell.com
Bacterial strains harboring the Yersinia pseudotuberculosis inv locus were analyzed in order
to investigate the mechanism of host cell penetration by an invasive pathogen. The inv locus …

Type IV pilus structure by cryo-electron microscopy and crystallography: implications for pilus assembly and functions

L Craig, N Volkmann, AS Arvai, ME Pique, M Yeager… - Molecular cell, 2006 - cell.com
Summary Type IV pili (T4P) are long, thin, flexible filaments on bacteria that undergo
assembly-disassembly from inner membrane pilin subunits and exhibit astonishing …

Membrane cofactor protein (MCP or CD46) is a cellular pilus receptor for pathogenic Neisseria

H Källström, MK Liszewski, JP Atkinson… - Molecular …, 1997 - Wiley Online Library
Pili of Neisseria gonorrhoeae and Neisseria meningitidis mediate binding of the bacteria to
human cell‐surface receptors. We found that purified pili bound to a 55‐to 60‐kDa doublet …

Phase variation of gonococcal pili by frameshift mutation in pilC, a novel gene for pilus assembly.

AB Jonsson, G Nyberg, S Normark - The EMBO journal, 1991 - embopress.org
Pili prepared from Neisseria gonorrhoeae contain minor amounts of a 110 kd outer
membrane protein denoted PilC. The corresponding gene exists in two copies, pilC1 and …

Differential roles of homologous recombination pathways in Neisseria gonorrhoeae pilin antigenic variation, DNA transformation and DNA repair

IJ Mehr, HS Seifert - Molecular microbiology, 1998 - Wiley Online Library
Neisseria gonorrhoeae (Gc) pili undergo antigenic variation when the amino acid sequence
of the pilin protein is changed, aiding in immune avoidance and altering pilus expression …

Opaque-white phenotype transition: a programmed morphological transition in Candida albicans

EH Rikkerink, BB Magee, PT Magee - Journal of bacteriology, 1988 - Am Soc Microbiol
This paper reports that the opaque and white phenotypes of Candida albicans constitute a
true high-frequency reversible transition system. The rDNA restriction fragment and …