Calcium (Ca) is a universal intracellular second messenger. In muscle, Ca is best known for
its role in contractile activation. However, in recent years the critical role of Ca in other …

Triggered activity in cardiac muscle and intracellular Ca2+ have been linked in the past.
However, today not only are there a number of cellular proteins that show clear Ca2+ …

Cryoelectron microscopy of biological molecules is among the hottest growth areas in
biophysics and structural biology at present, and Frank is arguably the most distinguished …

Among the most intriguing forms of Ca 2+ channel modulation is the regulation of L-type and
P/Q-type channels by intracellular Ca 2+, acting via unconventional channel-calmodulin …

Ca2+-dependent facilitation (CDF) of voltage-gated calcium current is a powerful
mechanism for up-regulation of Ca2+ influx during repeated membrane depolarization. CDF …

▪ Abstract A surprising variety of ion channels found in a wide range of species from Homo to
Paramecium use calmodulin (CaM) as their constitutive or dissociable Ca2+-sensing …

LS Maier and DM Bers. Calcium, Calmodulin, and Calcium-Calmodulin Kinase II: Heartbeat
to Heartbeat and Beyond. Journal of Molecular and Cellular Cardiology (2002) 34, 919–939 …

Abstract CaBP1–8 are neuronal Ca2+-binding proteins with similarity to calmodulin (CaM).
Here we show that CaBP4 is specifically expressed in photoreceptors, where it is localized …

Ca 2+-dependent inactivation (CDI) of L-type Ca 2+ channels plays a critical role in
controlling Ca 2+ entry and downstream signal transduction in excitable cells. Ca 2+ …

Abstract L-type (Ca V 1.2) and P/Q-type (Ca V 2.1) calcium channels possess lobe-specific
CaM regulation, where Ca 2+ binding to one or the other lobe of CaM triggers regulation …