Natural history of mesenchymal stem cells, from vessel walls to culture vessels

IR Murray, CC West, WR Hardy, AW James… - Cellular and Molecular …, 2014 - Springer
Mesenchymal stem/stromal cells (MSCs) can regenerate tissues by direct differentiation or
indirectly by stimulating angiogenesis, limiting inflammation, and recruiting tissue-specific …

Human mesenchymal stem cells: from immunophenotyping by flow cytometry to clinical applications

AA Nery, IC Nascimento, T Glaser… - Cytometry Part …, 2013 - Wiley Online Library
Modern medicine will unequivocally include regenerative medicine as a major breakthrough
in the re‐establishment of damaged or lost tissues due to degenerative diseases or injury. In …

MiR-133b promotes neural plasticity and functional recovery after treatment of stroke with multipotent mesenchymal stromal cells in rats via transfer of exosome …

H Xin, Y Li, Z Liu, X Wang, X Shang, Y Cui… - Stem …, 2013 - academic.oup.com
To test, in vivo, the hypothesis that exosomes from multipotent mesenchymal stromal cells
(MSCs) mediate microRNA 133b (miR-133b) transfer which promotes neurological recovery …

Mesenchymal stromal cell-associated migrasomes: a new source of chemoattractant for cells of hematopoietic origin

IA Deniz, J Karbanová, M Wobus, M Bornhäuser… - Cell Communication and …, 2023 - Springer
Background Multipotent mesenchymal stromal cells (MSCs) are precursors of various cell
types. Through soluble factors, direct cell–cell interactions and other intercellular …

Identification and validation of multiple cell surface markers of clinical-grade adipose-derived mesenchymal stromal cells as novel release criteria for good …

ET Camilleri, MP Gustafson, A Dudakovic… - Stem cell research & …, 2016 - Springer
Background Clinical translation of mesenchymal stromal cells (MSCs) necessitates basic
characterization of the cell product since variability in biological source and processing of …

[HTML][HTML] Novel markers of osteogenic and adipogenic differentiation of human bone marrow stromal cells identified using a quantitative proteomics approach

C Granéli, A Thorfve, U Ruetschi, H Brisby, P Thomsen… - Stem cell …, 2014 - Elsevier
Today, the tool that is most commonly used to evaluate the osteogenic differentiation of bone
marrow stromal cells (BMSCs) in vitro is the demonstration of the expression of multiple …

Comprehensive transcriptomic and proteomic characterization of human mesenchymal stem cells reveals source specific cellular markers

AM Billing, H Ben Hamidane, SS Dib, RJ Cotton… - Scientific reports, 2016 - nature.com
Mesenchymal stem cells (MSC) are multipotent cells with great potential in therapy, reflected
by more than 500 MSC-based clinical trials registered with the NIH. MSC are derived from …

The human transmembrane proteome

L Dobson, I Reményi, GE Tusnády - Biology Direct, 2015 - Springer
Background Transmembrane proteins have important roles in cells, as they are involved in
energy production, signal transduction, cell-cell interaction, cell-cell communication and …

Biological considerations in scaling up therapeutic cell manufacturing

DS Cherian, T Bhuvan, L Meagher… - Frontiers in …, 2020 - frontiersin.org
Cell therapeutics—using cells as living drugs—have made advances in many areas of
medicine. One of the most clinically studied cell-based therapy products is mesenchymal …

Single-cell RNA-seq of out-of-thaw mesenchymal stromal cells shows tissue-of-origin differences and inter-donor cell-cycle variations

C Medrano-Trochez, P Chatterjee, P Pradhan… - Stem cell research & …, 2021 - Springer
Abstract Background Human Mesenchymal stromal cells (hMSCs) from various tissue
sources are widely investigated in clinical trials. These MSCs are often administered to …