Mutants with defects in the rejoining of DNA double-strand breaks (dsbs) have been
identified and characterised from E. coli and the yeast, Saccharomyces cerevisiae. More …

Mutant rodent cell lines with hypersensitivity to DNA damage resulting from a defect in
cellular response to the damage have contributed to many of the recent advances in our …

To study the contribution of putative perforin-independent mechanism in the antigen-specific
target destruction by cytotoxic T lymphocytes, CD8+ CTL lines were established from spleen …

Telomere lengths in radiosensitive murine lymphoma cells L5178Y-S and parental
radioresistant L5178Y cells were measured by quantitative fluorescence in situ …

To better understand the basis for the difference in radiosensitivity between the variant
murine leukemic lymphoblast cell lines L5178Y-R (resistant) and L5178Y-S (sensitive), the …

The redox properties of iron make this metal a key participant in oxygen-mediated toxicity.
Accordingly, L5178Y (LY) mouse lymphoma cell lines, which display a unique inverse cross …

Two human lymphoblastoid cell lineages derived from the same parental line exhibit
markedly different survival and mutational responses to X-irradiation, but not to chemical …

The p53 tumor suppressor protein plays an important role in regulating the cellular response
to DNA damage, including cell cycle arrest and apoptosis induction. Normal p53 function is …

We have recently reported that local administration of anti-Fas monoclonal antibody (MAb)
in human T cell leukemia virus type 1 (HTLV-1) carrying mice improved arthritis due to the …

Mouse L5178Y strain LY-S and its parental strain LY-R differ in their comparative
sensitivities to the cytotoxic effects of various mutagenic agents--ie, strain LY-S has been …