HIV‐associated chronic immune activation

M Paiardini, M Müller‐Trutwin - Immunological reviews, 2013 - Wiley Online Library
Systemic chronic immune activation is considered today as the driving force of CD 4+ T‐cell
depletion and acquired immunodeficiency syndrome (AIDS). A residual chronic immune …

Natural SIV hosts: showing AIDS the door

A Chahroudi, SE Bosinger, TH Vanderford, M Paiardini… - Science, 2012 - science.org
Many species of African nonhuman primates are naturally infected with simian
immunodeficiency viruses (SIVs) in the wild and in captivity. In contrast to HIV-infected …

Programmed death-1–induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection

EA Said, FP Dupuy, L Trautmann, Y Zhang, Y Shi… - Nature medicine, 2010 - nature.com
Viral replication and microbial translocation from the gut to the blood during HIV infection
lead to hyperimmune activation, which contributes to the decline in CD4+ T cell numbers …

Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys

SE Bosinger, Q Li, SN Gordon, NR Klatt… - The Journal of …, 2009 - Am Soc Clin Investig
Natural SIV infection of sooty mangabeys (SMs) is nonprogressive despite chronic virus
replication. Strikingly, it is characterized by low levels of immune activation, while …

Low levels of SIV infection in sooty mangabey central memory CD4+ T cells are associated with limited CCR5 expression

M Paiardini, B Cervasi, E Reyes-Aviles, L Micci… - Nature medicine, 2011 - nature.com
Naturally simian immunodeficiency virus (SIV)-infected sooty mangabeys do not progress to
AIDS despite high-level virus replication. We previously showed that the fraction of CD4+ …

Acute loss of intestinal CD4+ T cells is not predictive of simian immunodeficiency virus virulence

IV Pandrea, R Gautam, RM Ribeiro… - The Journal of …, 2007 - journals.aai.org
The predictive value of acute gut-associated lymphoid tissue (GALT) CD4+ T cell depletion
in lentiviral infections was assessed by comparing three animal models illustrative of the …

Severe depletion of mucosal CD4+ T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeys

SN Gordon, NR Klatt, SE Bosinger… - The Journal of …, 2007 - journals.aai.org
HIV-infected humans and SIV-infected rhesus macaques experience a rapid and dramatic
loss of mucosal CD4+ T cells that is considered to be a key determinant of AIDS …

Understanding the benign nature of SIV infection in natural hosts

G Silvestri, M Paiardini, I Pandrea… - The Journal of …, 2007 - Am Soc Clin Investig
In striking contrast to HIV infection, natural SIV infection of African nonhuman primates is
asymptomatic and usually does not induce significant CD4+ T cell depletion despite high …

Going wild: lessons from naturally occurring T-lymphotropic lentiviruses

S VandeWoude, C Apetrei - Clinical microbiology reviews, 2006 - Am Soc Microbiol
Over 40 nonhuman primate (NHP) species harbor species-specific simian
immunodeficiency viruses (SIVs). Similarly, more than 20 species of nondomestic felids and …

Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts

DL Sodora, JS Allan, C Apetrei, JM Brenchley… - Nature medicine, 2009 - nature.com
The design of an effective AIDS vaccine has eluded the efforts of the scientific community to
the point that alternative approaches to classic vaccine formulations have to be considered …