Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a
high morbidity additionally, CRC patients may develop liver metastasis, which is the major …

A compelling long-term goal of cancer biology is to understand the crucial players during
tumorigenesis in order to develop new interventions. Here, we review how the four non …

Deregulation of angiogenesis–the growth of new blood vessels from an existing vasculature–
is a main driving force in many severe human diseases including cancer. As such, tumor …

Research on matrix metalloproteinases (MMPs) and in particular on gelatinase B, alias MMP-
9, has grown exponentially in the decade 2003–2012. Structural details about flexibility of …

Metastasis is the leading cause of cancer mortality. The metastatic cascade represents a
multi-step process which includes local tumor cell invasion, entry into the vasculature …

Tissue inhibitors of metalloproteinases (TIMPs) are widely distributed in the animal kingdom
and the human genome contains four paralogous genes encoding TIMPs 1 to 4. TIMPs were …

The ADAMs (a disintegrin and metalloproteinase) are a fascinating family of transmembrane
and secreted proteins with important roles in regulating cell phenotype via their effects on …

The biological roles of the matrix metalloproteinases (MMPs) have been traditionally
associated with the degradation and turnover of most of the components of the extracellular …

The tissue inhibitors of metalloproteinases (TIMPs) are well recognized for their role in
extracellular matrix remodeling by controlling the activity of matrix metalloproteinases …

Matrix metalloproteinases (MMPs) are reputed to cause the inflammatory tissue destruction
characterizing chronic inflammatory diseases and to degrade basement membrane …