In the past decades, a lot of effort has been put in identifying the role of matrix
metalloproteinases (MMPs) in cancer. The main role of MMPs in angiogenesis, tumor growth …

Retinal neovascularization and macular edema are central features of diabetic retinopathy,
the major cause of blindness in the developed world. Current treatments are limited in their …

A variety of therapeutic strategies in oncology are focused on the inhibition of tumor-induced
angiogenesis. Thus, there is a keen interest in methods which allow non-invasive monitoring …

Angiogenesis is a process of development and of growth of new capillary blood vessels from
pre-existing vessels. When pathological, it contributes to the development of numerous …

The integrin αvβ3 plays an important role in angiogenesis and tumor metastasis. It is
expressed on activated endothelial cells as well as some tumor cells. Therefore it is a …

Purpose: Endostatin is the first endogenous angiogenesis inhibitor to enter clinical trials.
Laboratory investigations with endostatin have indicated broad antitumor activity coupled …

Angiogenesis and inflammation are closely integrated processes in a number of
physiological and pathological conditions, including wound healing, psoriasis, diabetic …

Recent studies have suggested that inhibitors of 3-hydroxy-3-methyl-glutaryl-coenzyme A
reductase (statins) can play a role in protection against vascular risk, which is independent …

Angiogenesis, the generation of new capillaries through a process of pre‐existing
microvessel sprouting, is under stringent control and normally occurs only during embryonic …

It is generally accepted that vasculogenesis is limited to early embryogenesis and is
believed not to occur in adult, whereas angiogenesis occurs in both the developing embryo …