In humans, cell fusion is restricted to only a few cell types under normal conditions. In the
placenta, cell fusion is a critical process for generating syncytiotrophoblast: the giant …

BACKGROUND Villous cytotrophoblast (vCTB) is a precursor cell population that supports
the development of syncytiotrophoblast (vSTB), the high surface area barrier epithelium of …

Healthy progression of human pregnancy relies on cytotrophoblast (CTB) progenitor self-
renewal and its differentiation toward multinucleated syncytiotrophoblasts (STBs) and …

Background The placenta is essential for nutrient exchange and hormone production
between the mother and the developing fetus and serves as an invaluable model for …

Uterine spiral arteries are extensively remodeled during placentation to ensure sufficient
delivery of maternal blood to the developing fetus. Uterine spiral arterial remodeling is …

The syncytiotrophoblast is a human epithelial cell that is bathed in maternal blood on the
maternal-facing surface of the human placenta. It therefore acts as a barrier and exchange …

Background Prostate cancer is the leading cause of cancer in men, and its incidence
increases with age. Among other risk factors, pre-existing metabolic diseases have been …

Protein kinase C (PKC) is a multifunctional family of Ser-Thr kinases widely implicated in the
regulation of fundamental cellular functions, including proliferation, polarity, motility, and …

Atypical protein kinase-c (aPKC) isoforms are important regulators of polarity and stem cell
differentiation. There are three isoforms of aPKC: aPKC-ι, aPKC-ζ, and PKM-ζ. Recently …

The birth of Dolly through somatic cell nuclear transfer (SCNT) was a major scientific
breakthrough of the last century. Yet, while significant progress has been achieved across …