While few dispute the existence of the metabolic syndrome as a clustering of factors
indicative of poor metabolic health, its utility above that of its individual components in the …

The metabolic syndrome (MetS) is comprised of a cluster of closely related risk factors,
including visceral adiposity, insulin resistance, hypertension, high triglyceride, and low high …

Stratifying the management of type 2 diabetes (T2D) has to take into account marked
variability in patient phenotype due to heterogeneity in its pathophysiology, different stages …

Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder in
women of reproductive age. Its heterogeneous clinical presentation is characterized by …

Background Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous
syndrome, with several underlying etiologic and pathophysiologic factors. The presence of …

The pathophysiological mechanisms underlying the close relationship between
nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are multiple …

Toll-Like Receptor 9 (TLR9) is an ancient receptor integral to the primordial functions of
inflammation and metabolism. TLR9 functions to regulate homeostasis in a healthy system …

Abstract Background Metabolic syndrome (MetS) is a pathological condition characterized
by the abnormal clustering of several metabolic components and has become a major public …

During the course of evolution, up until the agricultural revolution, environmental fluctuations
forced the human species to develop a flexible metabolism in order to adapt its energy …

Prevalent and incident heart failure (HF) is increased in people with type 2 diabetes mellitus,
with risk directly associated with the severity of hyperglycemia. Furthermore, in patients with …