Targeting TGF-β signaling in cancer
S Colak, P Ten Dijke - Trends in cancer, 2017 - cell.com
The transforming growth factor (TGF)-β signaling pathway is deregulated in many diseases,
including cancer. In healthy cells and early-stage cancer cells, this pathway has tumor …
including cancer. In healthy cells and early-stage cancer cells, this pathway has tumor …
Transforming growth factor-β signaling pathway in colorectal cancer and its tumor microenvironment
Y Itatani, K Kawada, Y Sakai - International journal of molecular sciences, 2019 - mdpi.com
Transforming growth factor-beta (TGF-β) signaling is one of the important cellular pathways
that play key roles for tissue maintenance. In particular, it is important in the context of …
that play key roles for tissue maintenance. In particular, it is important in the context of …
Transforming growth factor β superfamily signaling in development of colorectal cancer
B Jung, JJ Staudacher, D Beauchamp - Gastroenterology, 2017 - Elsevier
Transforming growth factor (TGF)-β cytokines signal via a complex network of pathways to
regulate proliferation, differentiation, adhesion, migration, and other functions in many cell …
regulate proliferation, differentiation, adhesion, migration, and other functions in many cell …
TGF-β signaling in metastatic colorectal cancer (mCRC): from underlying mechanism to potential applications in clinical development
X Li, Y Wu, T Tian - International journal of molecular sciences, 2022 - mdpi.com
Colorectal cancer (CRC) is a serious public health issue, and it has the leading incidence
and mortality among malignant tumors worldwide. CRC patients with metastasis in the liver …
and mortality among malignant tumors worldwide. CRC patients with metastasis in the liver …
From inflammation to colitis-associated colorectal cancer in inflammatory bowel disease: Pathogenesis and impact of current therapies
MC Fantini, I Guadagni - Digestive and Liver Disease, 2021 - Elsevier
The risk of colorectal cancer (CRC) is higher in patients with inflammatory bowel disease
(IBD). Population-based data from patients with ulcerative colitis (UC) estimate that the risk …
(IBD). Population-based data from patients with ulcerative colitis (UC) estimate that the risk …
The difficulty in translating the preclinical success of combined TGFβ and immune checkpoint inhibition to clinical trial
AE Metropulos, HG Munshi, DR Principe - EBioMedicine, 2022 - thelancet.com
Immune checkpoint inhibitors (ICIs) have transformed the treatment paradigm for solid
tumors. However, even in cancers generally considered ICI-sensitive, responses can vary …
tumors. However, even in cancers generally considered ICI-sensitive, responses can vary …
Increased stiffness of the tumor microenvironment in colon cancer stimulates cancer associated fibroblast-mediated prometastatic activin A signaling
Colorectal cancer (CRC) is the second deadliest cancer in the US due to its propensity to
metastasize. Stromal cells and especially cancer-associated fibroblasts (CAF) play a critical …
metastasize. Stromal cells and especially cancer-associated fibroblasts (CAF) play a critical …
Long-term gemcitabine treatment reshapes the pancreatic tumor microenvironment and sensitizes murine carcinoma to combination immunotherapy
DR Principe, M Narbutis, S Kumar, A Park… - Cancer research, 2020 - AACR
Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related death with a
median survival time of 6–12 months. Most patients present with disseminated disease and …
median survival time of 6–12 months. Most patients present with disseminated disease and …
Curcumin induces apoptosis and cell cycle arrest via the activation of reactive oxygen species–independent mitochondrial apoptotic pathway in Smad4 and p53 …
A Agarwal, A Kasinathan, R Ganesan… - Nutrition Research, 2018 - Elsevier
Curcumin is a natural dietary polyphenol compound that has various pharmacological
activities such as antiproliferative and cancer-preventive activities on tumor cells. Indeed, the …
activities such as antiproliferative and cancer-preventive activities on tumor cells. Indeed, the …
[HTML][HTML] Exosome-mediated miR-200b promotes colorectal cancer proliferation upon TGF-β1 exposure
Z Zhang, T Xing, Y Chen, J Xiao - Biomedicine & pharmacotherapy, 2018 - Elsevier
Exosome are emerging mediators of intercellular communication. Cancer-secreted exosome
has an effect on the exosome donor cells and support cancer growth and metastasis. Here …
has an effect on the exosome donor cells and support cancer growth and metastasis. Here …