Seriously cilia: A tiny organelle illuminates evolution, disease, and intercellular communication
C Derderian, GI Canales, JF Reiter - Developmental cell, 2023 - cell.com
The borders between cell and developmental biology, which have always been permeable,
have largely dissolved. One manifestation is the blossoming of cilia biology, with cell and …
have largely dissolved. One manifestation is the blossoming of cilia biology, with cell and …
The role of motile cilia in the development and physiology of the nervous system
C Ringers, EW Olstad… - … Transactions of the …, 2020 - royalsocietypublishing.org
Motile cilia are miniature, whip-like organelles whose beating generates a directional fluid
flow. The flow generated by ciliated epithelia is a subject of great interest, as defective ciliary …
flow. The flow generated by ciliated epithelia is a subject of great interest, as defective ciliary …
[HTML][HTML] A new domestic cat genome assembly based on long sequence reads empowers feline genomic medicine and identifies a novel gene for dwarfism
The domestic cat (Felis catus) numbers over 94 million in the USA alone, occupies
households as a companion animal, and, like humans, suffers from cancer and common and …
households as a companion animal, and, like humans, suffers from cancer and common and …
Characterizing the morbid genome of ciliopathies
Background Ciliopathies are clinically diverse disorders of the primary cilium. Remarkable
progress has been made in understanding the molecular basis of these genetically …
progress has been made in understanding the molecular basis of these genetically …
Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain
Motile cilia defects impair cerebrospinal fluid (CSF) flow and can cause brain and spine
disorders. The development of ciliated cells, their impact on CSF flow, and their function in …
disorders. The development of ciliated cells, their impact on CSF flow, and their function in …
[HTML][HTML] Evolutionary proteomics uncovers ancient associations of cilia with signaling pathways
MA Sigg, T Menchen, C Lee, J Johnson… - Developmental cell, 2017 - cell.com
Cilia are organelles specialized for movement and signaling. To infer when during evolution
signaling pathways became associated with cilia, we characterized the proteomes of cilia …
signaling pathways became associated with cilia, we characterized the proteomes of cilia …
A phylogenetic profiling approach identifies novel ciliogenesis genes in Drosophila and C. elegans
J Dobbelaere, TY Su, B Erdi, A Schleiffer… - The EMBO …, 2023 - embopress.org
Cilia are cellular projections that perform sensory and motile functions in eukaryotic cells. A
defining feature of cilia is that they are evolutionarily ancient, yet not universally conserved …
defining feature of cilia is that they are evolutionarily ancient, yet not universally conserved …
Discovery of a genetic module essential for assigning left–right asymmetry in humans and ancestral vertebrates
E Szenker-Ravi, T Ott, M Khatoo… - Nature Genetics, 2022 - nature.com
The vertebrate left–right axis is specified during embryogenesis by a transient organ: the left–
right organizer (LRO). Species including fish, amphibians, rodents and humans deploy …
right organizer (LRO). Species including fish, amphibians, rodents and humans deploy …
[HTML][HTML] The developmental biology of kinesins
Kinesins are microtubule-based motor proteins that are well known for their key roles in cell
biological processes ranging from cell division, to intracellular transport of mRNAs, proteins …
biological processes ranging from cell division, to intracellular transport of mRNAs, proteins …
De novo and recessive forms of congenital heart disease have distinct genetic and phenotypic landscapes
The genetic architecture of sporadic congenital heart disease (CHD) is characterized by
enrichment in damaging de novo variants in chromatin-modifying genes. To test the …
enrichment in damaging de novo variants in chromatin-modifying genes. To test the …