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Much progress has been made over the past decade with the development of novel
methods for addressing increasingly more complex multiplicity problems arising in …

Background Bullous pemphigoid is a blistering skin disorder with increased mortality. We
tested whether a strategy of starting treatment with doxycycline gives acceptable short-term …

Selecting the most appropriate end points for clinical trials is important to assess the value of
new treatment strategies. Well-established end points for clinical research exist in oncology …

Bringing together leading statisticians, scientists, and clinicians from the pharmaceutical
industry, academia, and regulatory agencies, this volume explores the rapidly growing area …

This tutorial discusses important statistical problems arising in clinical trials with multiple
clinical objectives based on different clinical variables, evaluation of several doses or …

Maintaining a practical perspective, Bioequivalence and Statistics in Clinical Pharmacology,
Second Edition explores statistics used in day-to-day clinical pharmacology work. The book …

Nutrigenetics and nutrigenomics, combined with the omics technologies, are a demanding
and an increasingly important field in personalizing nutrition-based care to understand an …

A common approach to analysing clinical trials with multiple outcomes is to control the
probability for the trial as a whole of making at least one incorrect positive finding under any …

BACKGROUND: The Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) has
been used widely as a cognitive end point in Alzheimer's Disease (AD) clinical trials. Efforts …