T cell acute lymphoblastic leukaemia (T-ALL) is an aggressive haematological malignancy
derived from early T cell progenitors. In recent years genomic and transcriptomic studies …

Structural chromosome rearrangements may result in the exchange of coding or regulatory
DNA sequences between genes. Many such gene fusions are strong driver mutations in …

Uterine leiomyomas are benign smooth-muscle tumors of extremely low malignant potential.
Early work utilizing classical cytogenetics revealed that a subset of uterine leiomyomas …

The most common pediatric malignancy is acute lymphoblastic leukemia (ALL), of which T‐
cell ALL (T‐ALL) comprises 10–15% of cases. T‐ALL arises in the thymus from an immature …

Abstract The Insulin Receptor Substrate (IRS) proteins are cytoplasmic adaptor proteins that
function as essential signaling intermediates downstream of activated cell surface receptors …

T-cell acute lymphoblastic leukemia/lymphoma (T-ALL) is characterized by aberrant
activation of NOTCH1 in over 60% of T-ALL cases. The high prevalence of activating …

Simple Summary IRS4 (insulin receptor substrate4) belongs to a family of intracellular
proteins that include IRS1 and IRS2 and whose physiological function is to transmit the …

In search of oncogenic drivers and mechanisms affecting therapy resistance in breast
cancer, we identified Irs4, a poorly studied member of the insulin receptor substrate (IRS) …

Acute lymphoblastic leukaemia (ALL) is a haematological malignancy characterized by the
uncontrolled proliferation of immature lymphoid cells. Over past decades, significant …

The IKZF 1 gene at 7p12. 2 codes for IKAROS (also termed IKZF 1), an essential
transcription factor in haematopoiesis involved primarily in lymphoid differentiation. Its …