Control of sleep and wakefulness
This review summarizes the brain mechanisms controlling sleep and wakefulness.
Wakefulness promoting systems cause low-voltage, fast activity in the …
Wakefulness promoting systems cause low-voltage, fast activity in the …
Neuronal mechanisms for sleep/wake regulation and modulatory drive
A Eban-Rothschild, L Appelbaum… - …, 2018 - nature.com
Humans have been fascinated by sleep for millennia. After almost a century of scientific
interrogation, significant progress has been made in understanding the neuronal regulation …
interrogation, significant progress has been made in understanding the neuronal regulation …
[PDF][PDF] Two dopaminergic neurons signal to the dorsal fan-shaped body to promote wakefulness in Drosophila
Background The neuronal circuitry underlying sleep is poorly understood. Although
dopamine (DA) is thought to play a key role in sleep/wake regulation, the identities of the …
dopamine (DA) is thought to play a key role in sleep/wake regulation, the identities of the …
Molecular mechanisms of sleep homeostasis in flies and mammals
Sleep is homeostatically regulated with sleep pressure accumulating with the increasing
duration of prior wakefulness. Yet, a clear understanding of the molecular components of the …
duration of prior wakefulness. Yet, a clear understanding of the molecular components of the …
A Critical Period of Sleep for Development of Courtship Circuitry and Behavior in Drosophila
MS Kayser, Z Yue, A Sehgal - Science, 2014 - science.org
Most animals sleep more early in life than in adulthood, but the function of early sleep is not
known. Using Drosophila, we found that increased sleep in young flies was associated with …
known. Using Drosophila, we found that increased sleep in young flies was associated with …
[PDF][PDF] Two different forms of arousal in Drosophila are oppositely regulated by the dopamine D1 receptor ortholog DopR via distinct neural circuits
T Lebestky, JSC Chang, H Dankert, L Zelnik, YC Kim… - Neuron, 2009 - cell.com
Arousal is fundamental to many behaviors, but whether it is unitary or whether there are
different types of behavior-specific arousal has not been clear. In Drosophila, dopamine …
different types of behavior-specific arousal has not been clear. In Drosophila, dopamine …
Dopamine dynamics and signaling in Drosophila: an overview of genes, drugs and behavioral paradigms
S Yamamoto, ES Seto - Experimental animals, 2014 - jstage.jst.go.jp
Changes in dopamine (DA) signaling have been implicated in a number of human
neurologic and psychiatric disorders. Similarly, defects in DA signaling in the fruit fly …
neurologic and psychiatric disorders. Similarly, defects in DA signaling in the fruit fly …
[PDF][PDF] Morning and evening circadian pacemakers independently drive premotor centers via a specific dopamine relay
Many animals exhibit morning and evening peaks of locomotor behavior. In Drosophila, two
corresponding circadian neural oscillators—M (morning) cells and E (evening) cells—exhibit …
corresponding circadian neural oscillators—M (morning) cells and E (evening) cells—exhibit …
[PDF][PDF] WIDE AWAKE mediates the circadian timing of sleep onset
How the circadian clock regulates the timing of sleep is poorly understood. Here, we identify
a Drosophila mutant, wide awake (wake), that exhibits a marked delay in sleep onset at …
a Drosophila mutant, wide awake (wake), that exhibits a marked delay in sleep onset at …
Genome-wide association study of sleep in Drosophila melanogaster
ST Harbison, LJ McCoy, TFC Mackay - BMC genomics, 2013 - Springer
Background Sleep is a highly conserved behavior, yet its duration and pattern vary
extensively among species and between individuals within species. The genetic basis of …
extensively among species and between individuals within species. The genetic basis of …