The small (40S) subunit of eukaryotic ribosomes is believed to bind initially at the capped 5'-
end of messenger RNA and then migrate, stopping at the first AUG codon in a favorable …

Abstract The Rho family of GTPases represents a class of Ras-related signaling molecules
often deregulated in cancer. Rho GTPases switch from a GDP-bound, inactive state to a GTP …

Summary c-Jun amino-terminal kinases (JNKs) and mitogen-activatedprotein kinases
(MAPKs) are closely related; however, they are independently regulated by a variety of …

Src homology 2 (SH2) domains provide specificity to intracellular signaling by binding to
specific phosphotyrosine (phospho-Tyr)-containing sequences. We recently developed a …

rho-like GTP binding proteins play an essential role in regulating cell growth and actin
polymerization. These molecular switches are positively regulated by guanine nucleotide …

Genetic screening and biochemical studies during the past few years have led to the
discovery of a family of cell growth regulatory proteins and oncogene products for which the …

THE superfamily of low molecular mass GTP-binding proteins, for which the ras proteins are
prototypes, has been implicated in the regulation of diverse biological activities including …

A novel human gene, encoding a 188 amino acid polypeptide that contains a region similar
to that of the epidermal growth factor, has been isolated. The gene, expressed in …

A putative Akt kinase phosphorylation site (64 ydRIRplSYp 73) was found in Rac1/CDC42
and Rho family proteins (RhoA, RhoB, RhoC, and RhoG). Phosphorylation of Rac1 by Akt …

The dbl oncogene product contains a 238-amino acid domain, which is shared by an
expanding family of growth regulatory proteins. These include the Saccharomyces …