The hypothesis that differences in gene regulation have an important role in speciation and
adaptation is more than 40 years old. With the advent of new sequencing technologies, we …

Gene expression is central to the genotype-phenotype relationship in all organisms, and it is
an important component of the genetic basis for evolutionary change in diverse aspects of …

Enhanced cognitive function in humans is hypothesized to result from cortical expansion
and increased cellular diversity. However, the mechanisms that drive these phenotypic …

Ultra-high-throughput sequencing is emerging as an attractive alternative to microarrays for
genotyping, analysis of methylation patterns, and identification of transcription factor binding …

In apparently scale-free protein–protein interaction networks, or 'interactome'networks,, most
proteins interact with few partners, whereas a small but significant proportion of proteins, the …

Differences in gene expression are central to evolution. Such differences can arise from cis-
regulatory changes that affect transcription initiation, transcription rate and/or transcript …

A substantial amount of phenotypic diversity results from changes in gene expression levels
and patterns. Understanding how the transcriptome evolves is therefore a key priority in …

Polyploidy is a common mode of evolution in flowering plants. The profound effects of
polyploidy on gene expression appear to be caused more by hybridity than by genome …

The observation that animal morphology tends to be conserved during the embryonic
phylotypic period (a period of maximal similarity between the species within each animal …

The regulation of gene expression is critical for organismal function and is an important
source of phenotypic diversity between species. Understanding the genetic and molecular …