H 2 O 2 signals trigger adaptive responses affecting cell division, differentiation, migration,
and survival. These signals are transduced by selective oxidation of cysteines on specific …

Three decades of research on the biochemistry of peroxynitrite (ONOOH/ONOO−) have
established that this stealthy oxidant is formed in biological systems, and that its main targets …

Redox-based protein posttranslational modifications, such as S-nitrosylation of critical,
active site cysteine thiols have garnered significant clinical attention and research interest …

Hydroperoxides (ROOHs) are known as damaging agents capable of mediating mutation,
while a role as signaling agents through oxidation of protein sulfhydryls that can alter cancer …

Abstract Hydrogen peroxide (H 2 O 2) is an important biological molecule, functioning both
as a second messenger in cell signaling and, especially at higher concentrations, as a …

In the cytosol of human cells under low oxidative loads, hydrogen peroxide is confined to
microdomains around its supply sites, due to its fast consumption by peroxiredoxins. So are …

Human peroxiredoxin 1 and peroxiredoxin 2 (HsPrx1 and HsPrx2), both cytosolic
antioxidant enzymes share more than 90% sequence similitude, peroxide substrate …

Hydrogen peroxide (H2O2) is an important biological molecule, functioning both as a
second messenger in cell signaling and, especially at higher concentrations, as a cause of …

Three decades of research on the biochemistry of peroxynitrite (ONOOH/ONOO) have
established that this stealthy oxidant is formed in biological systems, and that its main targets …