How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions

RM Sapolsky, LM Romero, AU Munck - Endocrine reviews, 2000 - academic.oup.com
The secretion of glucocorticoids (GCs) is a classic endocrine response to stress. Despite
that, it remains controversial as to what purpose GCs serve at such times. One view …

Stress and cognitive function

BS McEwen, RM Sapolsky - Current opinion in neurobiology, 1995 - Elsevier
Stress affects cognition in a number of ways, acting rapidly via catecholamines and more
slowly via glucocorticoids. Catecholamine actions involve beta adrenergic receptors and …

Lactate produced by glycogenolysis in astrocytes regulates memory processing

LA Newman, DL Korol, PE Gold - PloS one, 2011 - journals.plos.org
When administered either systemically or centrally, glucose is a potent enhancer of memory
processes. Measures of glucose levels in extracellular fluid in the rat hippocampus during …

Effects of β-hydroxybutyrate on cognition in memory-impaired adults

MA Reger, ST Henderson, C Hale, B Cholerton… - Neurobiology of …, 2004 - Elsevier
Glucose is the brain's principal energy substrate. In Alzheimer's disease (AD), there appears
to be a pathological decrease in the brain's ability to use glucose. Neurobiological evidence …

The longer-term impacts of Western diet on human cognition and the brain

H Francis, R Stevenson - Appetite, 2013 - Elsevier
Animal work over the last three decades has generated a convincing body of evidence that a
Western diet–one high in saturated fat and refined carbohydrates (HFS diet)–can damage …

Memory improvement following induced hyperinsulinemia in Alzheimer's disease

S Craft, J Newcomer, S Kanne, S Dagogo-Jack… - Neurobiology of …, 1996 - Elsevier
Dementia of the Alzheimer type (DAT) is accompanied by disruption in glucose regulation
and utilization that may contribute to its characteristic memory impairment. Increasing …

Insulin receptors and insulin action in the brain: review and clinical implications

RJ Schulingkamp, TC Pagano, D Hung… - … & Biobehavioral Reviews, 2000 - Elsevier
Insulin receptors are known to be located on nerve cells in mammalian brain. The binding of
insulin to dimerized receptors stimulates specialized transporter proteins that mediate the …

Brain injury with diabetes mellitus: evidence, mechanisms and treatment implications

SA Hamed - Expert review of clinical pharmacology, 2017 - Taylor & Francis
Introduction: Diabetes mellitus is a risk for brain injury. Brain injury is associated with acute
and chronic hyperglycaemia, insulin resistance, hyperinsulinemia, diabetic ketoacidosis …

Glucose transporter expression in the central nervous system: relationship to synaptic function

BS McEwen, LP Reagan - European journal of pharmacology, 2004 - Elsevier
The family of facilitative glucose transporter (GLUT) proteins is responsible for the entry of
glucose into cells throughout the periphery and the brain. The expression, regulation and …

Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer's disease and cardiovascular disease

IJ Martins, E Hone, JK Foster, SI Sünram-Lea… - Molecular …, 2006 - nature.com
High fat diets and sedentary lifestyles are becoming major concerns for Western countries.
They have led to a growing incidence of obesity, dyslipidemia, high blood pressure, and a …