Insects, like all eukaryotes, require sterols for structural and metabolic purposes. However,
insects, like all arthropods, cannot make sterols. Cholesterol is the dominant tissue sterol for …

Proteins, nucleic acids, and lipids are three major components of the cell. Despite a few
basic metabolic pathways, we know very little about lipids, compared with the explosion of …

The Drosophila testis has numerous advantages for the study of basic cellular processes, as
production of sperm requires a highly orchestrated and complex combination of …

ML (MD-2 (myeloid differentiation factor-2)-related Lipid-recognition) is a conserved domain
identified in MD-2, MD-1, NPC2 (Niemann-Pick disease type C2), and mite major allergen …

Spermatid elongation is a crucial event in the late stage of spermatogenesis in the
Drosophila testis, eventually leading to the formation of mature sperm after meiosis. During …

Interactions between the soma and germline are essential for gametogenesis. In the
Drosophila testis, differentiating germ cells are encapsulated by two somatic cells that …

Insect steroid hormones (ecdysteroids) are important for female reproduction in many insect
species and are required for the initiation and coordination of vital developmental …

Successful completion of gametogenesis is critical for perpetuation of the species. In
addition to the inherent interest, studies of gamete development, in particular …

Efficient production of high-quality semen is a crucial trait in the dairy cattle breeding due to
the widespread use of artificial insemination. However, the genetic architecture (eg …

The Drosophila annotated gene CG5155 encodes a protein that contains 10 Armadillo-
repeats and has an unknown function. To fill this gap, we performed loss-of-function studies …